Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

The transcription factor nuclear factor erythroid-derived 2-like 2 (NRF2) participates in the
activation of the antioxidant cytoprotective pathway and other important physiological …

The glutathione S-transferases (GST) represent a major group of detoxification enzymes. All
eukaryotic species possess multiple cytosolic and membrane-bound GST isoenzymes, each …

Increases in the intracellular levels of reactive oxygen species (ROS), frequently referred to
as oxidative stress, respresents a potentially toxic insult which if not counteracted will lead to …

Induction of phase 2 detoxication enzymes [eg, glutathione transferases, epoxide hydrolase,
NAD (P) H: quinone reductase, and glucuronosyltransferases] is a powerful strategy for …

Covering: 2000 to 2013 Oxidative stress is the central component of chronic diseases. The
nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway …

The expression of genes encoding antioxidative and Phase II detoxification enzymes is
induced in cells exposed to electrophilic compounds and phenolic antioxidants. Induction of …

▪ Abstract Reactive oxygen intermediates are produced in all aerobic organisms during
respiration and exist in the cell in a balance with biochemical antioxidants. Excess reactive …

Abstract Aflatoxin B 1 (AFB 1) widely contaminates staple food and feed crops and is well-
known as the most potent natural hepatocarcinogen in humans and domesticated animals …