Publisher Summary Antioxidants inhibit the propagation of free radical reactions. Because of
their widespread use as preservatives in processed foods, their biochemical effects have …

Human colon carcinoma Caco-2 cells were used to study the induction of UDP
glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A9, and UGT2B7 by aryl …

γ-Glutamylcysteine synthetase (GCS), the rate-limiting enzyme in the de novo synthesis of
GSH, is a heterodimer, consisting of a catalytic (GCSh) and a regulatory subunit (GCSl). We …

Endoplasmic reticulum (ER) stress is involved in neurodegenerative diseases including
Alzheimer's disease (AD), in which dysregulation of double-stranded RNA-dependent …

Abstract NAD (P) H: quinone oxidoreductase (QR) and glutathione‐S‐transferases (GSTs)
are among the enzymes believed to protect an organism against oxidative stress. To test if …

Expression of the transcription factor Ets‐1 is increasingly associated with the progression of
several human cancers. A tumor‐derived factor is expected to be involved in the …

Polycyclic aromatic hydrocarbons (PAH) contained in fossil fuel combustion particles
enhance the allergic response to common environmental Ags. A key question is: what are …

Metallothioneins (MTs) are cysteine-rich metal-binding proteins that are potentially involved
in zinc homeostasis and free radical scavenging. The expression pattern of MT-1 and the …

Environmental and occupational exposure to chromium compounds, especially hexavalent
chromium [Cr (VI)], is widely recognized as a potential nephrotoxic in humans and animals …

Cells exposed to oxidative stress or electrophilic xenobiotics respond by transcriptionally up-
regulating a battery of genes that contain a cis-acting element in their promoter region …