[HTML][HTML] How zoledronic acid improves osteoporosis by acting on osteoclasts

B Wang, Y Zhan, L Yan, D Hao - Frontiers in Pharmacology, 2022 - frontiersin.org
Osteoporosis is called a silent disease, because it is difficult to detect until comprehensive
examinations for osteoporosis are performed or osteoporotic fractures occur. Zoledronic acid …

[HTML][HTML] In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

P Samakkarnthai, D Saul, L Zhang, Z Aversa… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
In addition to reducing fracture risk, zoledronic acid has been found in some studies to
decrease mortality in humans and extend lifespan and healthspan in animals. Because …

Inhibiting Osteolytic Breast Cancer Bone Metastasis by Bone‐Targeted Nanoagent via Remodeling the Bone Tumor Microenvironment Combined with NIR‐II …

Y Zeng, Z Pan, J Yuan, Y Song, Z Feng, Z Chen, Z Ye… - Small, 2023 - Wiley Online Library
Bone is one of the prone metastatic sites of patients with advanced breast cancer. The
“vicious cycle” between osteoclasts and breast cancer cells plays an essential role in …

[HTML][HTML] Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL‑mediated NF‑κB and JNK and their downstream signalling …

XL Huang, C Liu, XM Shi… - Molecular …, 2022 - spandidos-publications.com
Targeting excessive osteoclast differentiation and activity is considered a valid therapeutic
approach for osteoporosis. Zoledronic acid (ZOL) plays a pivotal role in regulating bone …

[HTML][HTML] METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs

Y Jin, X Han, Y Wang, Z Fan - International Journal of Oral Science, 2024 - nature.com
Bisphosphonate-related osteonecrosis of jaw (BRONJ) is characterized by impaired
osteogenic differentiation of orofacial bone marrow stromal cells (BMSCs). Corin has …

唑来膦酸干预去势大鼠牙槽骨骨代谢及核苷酸结合寡聚化结构域样受体蛋白3 炎症小体表达的变化

霍花, 刘官娟, 宋娜, 周倩, 程余婷, 罗珊珊, 廖健 - 中国组织工程研究, 2022 - cjter.com
唑来膦酸干预去势大鼠牙槽骨骨代谢及核苷酸结合寡聚化结构域样受体蛋白3 炎症小体表达的变
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Local application of zoledronate inhibits early bone resorption and promotes bone formation

MK Hsieh, CY Wang, FC Kao, HT Su, MF Chen… - JBMR plus, 2024 - academic.oup.com
Nonunion resulting from early bone resorption is common after bone transplantation
surgery. In these patients, instability or osteoporosis causes hyperactive catabolism relative …

In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers

P Samakkarnthai, D Saul, L Zhang, Z Aversa… - bioRxiv, 2023 - biorxiv.org
In addition to reducing fracture risk, zoledronate has been found in some studies to
decrease mortality in humans and extend lifespan and healthspan in animals. Because …

[HTML][HTML] Oestradiol contributes to differential antitumour effects of adjuvant zoledronic acid observed between pre-and post-menopausal women

VG Canuas-Landero, CN George, DV Lefley… - Frontiers in …, 2021 - frontiersin.org
Clinical trials have demonstrated that adding zoledronic acid (Zol) to (neo) adjuvant
standard of care has differential antitumour effects in pre-and post-menopausal women …

唑来膦酸促进去势大鼠牙槽骨的成骨作用

宋娜, 刘官娟, 程余婷, 熊玥, 罗珊珊, 洪伟, 廖健 - 中国组织工程研究, 2023 - cjter.com
唑来膦酸促进去势大鼠牙槽骨的成骨作用 Page 1 4494|中国组织工程研究|第27卷|第28期|2023年
10月 中国组织工程研究 Chinese Journal of Tissue Engineering Research www.CJTER.com …