Mechanistic insight into the design of chemical tools to control multiple pathogenic features in Alzheimer's disease
Conspectus Alzheimer's disease (AD) is the most common form of dementia and is
characterized by memory loss and cognitive decline. Approximately 50 million people …
characterized by memory loss and cognitive decline. Approximately 50 million people …
[HTML][HTML] Protein misfolding and aggregation in proteinopathies: causes, mechanism and cellular response
MR Ajmal - Diseases, 2023 - mdpi.com
Proteins are central to life functions. Alterations in the structure of proteins are reflected in
their function. Misfolded proteins and their aggregates present a significant risk to the cell …
their function. Misfolded proteins and their aggregates present a significant risk to the cell …
Role of sugar osmolytes and their nano-counterparts as inhibitors in protein fibrillation
Protein aggregation is responsible for various human diseases, ie Alzheimer's, Parkinson's,
Huntington's as well as cataract. Finding molecular drugs which could prevent protein …
Huntington's as well as cataract. Finding molecular drugs which could prevent protein …
Inhibiting protein aggregation by small molecule-based colloidal nanoparticles
Conspectus Protein aggregation is associated with different human diseases such as
Alzheimer's, Huntington's, Parkinson's, diabetes type II, and cataracts. Currently no effective …
Alzheimer's, Huntington's, Parkinson's, diabetes type II, and cataracts. Currently no effective …
Polyisobutylene-based glycopolymers as potent inhibitors for in vitro insulin aggregation
A family of amphiphilic diblock copolymers containing a hydrophobic polyisobutylene (PIB,
Mn= 1000 g mol− 1) segment and a hydrophilic block with sugar pendants has been …
Mn= 1000 g mol− 1) segment and a hydrophilic block with sugar pendants has been …
Side‐chain amino‐acid‐based polymers: self‐assembly and bioapplications
The design and development of side‐chain amino‐acid‐based polymeric nanostructures
have attracted a significant research interest as they bring a remarkable revolution in various …
have attracted a significant research interest as they bring a remarkable revolution in various …
Mechanistic Insight into the Amyloid Fibrillation Inhibition of Hen Egg White Lysozyme by Three Different Bile Acids
NA Jamuna, A Kamalakshan… - The Journal of …, 2023 - ACS Publications
Amyloid aggregation of protein is linked to many neurodegenerative diseases. Identification
of small molecules capable of targeting amyloidogenic proteins has gained significant …
of small molecules capable of targeting amyloidogenic proteins has gained significant …
From small molecules to polymeric probes: recent advancements of formaldehyde sensors
S Pan, S Roy, N Choudhury, PP Behera… - … and Technology of …, 2022 - Taylor & Francis
Formaldehyde is a well-known industrial material regularly used in fishery, vegetable
markets, and fruit shops for maintaining their freshness. But due to its carcinogenic nature …
markets, and fruit shops for maintaining their freshness. But due to its carcinogenic nature …
Illustrating the effect of small molecules derived from natural resources on amyloid peptides
R Roy, S Paul - The Journal of Physical Chemistry B, 2023 - ACS Publications
The onset of amyloidogenic diseases is associated with the misfolding and aggregation of
proteins. Despite extensive research, no effective therapeutics are yet available to treat …
proteins. Despite extensive research, no effective therapeutics are yet available to treat …
A bioinspired stimuli-responsive amino acid-based antibacterial drug delivery system in cancer therapy
The chronic bacterial inflammation triggered by microbiota is a well-established induction
factor promoting colitis-associated colorectal cancer (CRC) and inflammatory bowel …
factor promoting colitis-associated colorectal cancer (CRC) and inflammatory bowel …