Sleep timing is controlled by the subtle interplay between circadian and homeostatic
oscillators which, according to their endogenous properties, allow beings to feel …

Mental fatigue reflects a change in psychobiological state, caused by prolonged periods of
demanding cognitive activity. It has been well documented that mental fatigue impairs …

Purinergic neurotransmission, involving release of ATP as an efferent neurotransmitter was
first proposed in 1972. Later, ATP was recognised as a cotransmitter in peripheral nerves …

Sleep is one of the most pervasive biological phenomena, but one whose function remains
elusive. Although many theories of function, indirect evidence, and even common sense …

Sleep is the most important period for recovery from daily load. Regular physical activity
enhances overall sleep quality, but the effects of acute exercise on sleep are not well …

# 1 NEW YORK TIMES BESTSELLER• OVER ONE MILLION COPIES SOLD• A
groundbreaking manifesto on living better and longer that challenges the conventional …

Epilepsy, one of the most severe neurological diseases, is characterized by abrupt recurrent
seizures. Despite great progress in the development of antiseizure drugs (ASDs) based on …

Objective: Anxiety symptoms are common in older adults with or without anxiety disorders.
Pharmacological options may be limited for these patients. Alternative treatments, such as …

L'actuelle pandémie de la maladie à coronavirus 2019 (COVID-19) et la mise en vigueur de
politiques de confinement ont donné lieu à d'importants changements dans la routine …

For many years the neuromodulator adenosine has been recognized as an endogenous
anticonvulsant molecule and termed a “retaliatory metabolite.” As the core molecule of ATP …