The metastatic process, ie the dissemination of cancer cells throughout the body to seed
secondary tumors at distant sites, requires cancer cells to leave the primary tumor and to …

Cancer cells possess a broad spectrum of migration and invasion mechanisms. These
include both individual and collective cell-migration strategies. Cancer therapeutics that are …

The number of available breast cancer cell (BCC) lines is small, and only a very few of them
have been extensively studied. Whether they are representative of the tumours from which …

Matrix metalloproteinases (MMPs) are believed to play a pivotal role in malignant behavior
of cancer cells such as rapid tumor growth, invasion, and metastasis by degrading …

With the goal of identifying genes that have an expression pattern that can facilitate the
diagnosis of primary breast cancers (BCs) as well as the discovery of novel drug leads for …

The matrix metalloproteinases (MMP) have been implicated in tumor invasion and
metastasis both by immunohistochemical studies and from the observation that specific …

Matrix metalloproteinases (MMP) degrade components of extracellular matrix (ECM), and
thereby regulate formation, remodeling and maintenance of tissue. Abnormal function of cell …

Activation of the matrix metalloproteinase 2 (MMP-2) has been shown to play a major role in
the proteolysis of extracellular matrix (ECM) associated with tumor invasion. Although the …

The expression of Smad interacting protein-1 (SIP1; ZEB2) and the de novo expression of
vimentin are frequently involved in epithelial-to-mesenchymal transitions (EMTs) under both …

Loss of E-cadherin expression is a major characteristic of highly invasive and metastatic
cancers. Epithelial-mesenchymal transition (EMT) has been advocated to be a causative …