History shows that metal-based drugs and remedies have been known and used since very
ancient times. For example, silver was employed in the treatment of wounds and ulcers …

Gold complexes have recently gained increasing attention in the design of new metal-based
anticancer therapeutics. Gold (III) complexes are generally reactive/unstable under …

Metallodrugs offer potential for unique mechanisms of drug action based on the choice of
the metal, its oxidation state, the types and number of coordinated ligands and the …

A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …

Countless expectations converge in the multidisciplinary endeavour for the search and
development of effective and safe drugs in fighting cancer. Although they still embody a …

Golden times for metal‐based drugs? Alkynyl triphenylphosphine gold (I) complexes display
interesting biological properties and show high potential for future drug development. They …

Phosphines are the most studied ligands on gold-based metallodrugs, whereas N-
heterocyclic carbenes (NHCs) have been emerging in the past years as potential alternative …

An overview of the homometallic phosphine-Au (I) alkynyl complexes reported in the
literature from 2010 to 2018 have been collected and reported in this review article. They …

Metabolic reprogramming is a key cancer hallmark that has led to the therapeutic targeting
of glycolysis. However, agents that target dysfunctional mitochondrial respiration for targeted …

Owing to the growing hardware capabilities and the enhancing efficacy of computational
methodologies, computational chemistry approaches have constantly become more …