The poor oral bioavailability arising from poor aqueous solubility should make drug research
and development more difficult. Various approaches have been developed with a focus on …

Solid dispersions are one of the most promising strategies to improve the oral bioavailability
of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and …

Curcumin (CCM) is one of the most frequently explored plant compounds with various
biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and …

Objectives With poorly soluble drug candidates emerging in the drug discovery pipeline, the
importance of the solid dispersion formulation approach is increasing. This strategy includes …

As part of achieving national environmental goals, the Swedish Government commissioned
an official report from the Swedish Medical Products Agency on environmental effects of …

Background: In the US, manufacturers seeking approval to market a generic drug product
must submit data demonstrating that the generic formulation provides the same rate and …

Discovery of several poorly water soluble drugs in the past decade has led to the constant
need of developing a novel dosage form which increases the solubility of these drug. They …

Ritonavir is an antiretroviral drug characterized by low solubility and high permeability which
corresponds to BCS class II drug. The purpose of the study was to develop solid dispersion …

For discovery teams working toward new, orally administered therapeutic agents, one
requirement is to attain adequate systemic exposure after oral dosing, which is best …

It is estimated that more than 40% of new chemical entities (NCEs) coming out of the current
drug discovery process have poor biopharmaceutical properties, such as low aqueous …