[HTML][HTML] Galectin-10 as a potential biomarker for eosinophilic diseases

H Tomizawa, Y Yamada, M Arima, Y Miyabe… - Biomolecules, 2022 - mdpi.com
Galectin-10 is a member of the lectin family and one of the most abundant cytoplasmic
proteins in human eosinophils. Except for some myeloid leukemia cells, basophils, and …

Treatments of refractory eosinophilic lung diseases with biologics

K Asano, Y Suzuki, J Tanaka, K Kobayashi… - Allergology …, 2023 - jstage.jst.go.jp
abstract Biologics targeting the molecules associated with type 2 inflammation have
significantly improved the outcomes of patients with severe eosinophilic asthma and chronic …

Two‐year results of tapered dupilumab for CRSwNP demonstrates enduring efficacy established in the first 6 months

RJL van der Lans, JJ Otten, GFJPM Adriaensen… - Allergy, 2023 - Wiley Online Library
Background Dupilumab is an anti‐T2‐inflammatory biological registered for chronic
rhinosinusitis (CRS) with nasal polyps (CRSwNP), indicated by integrated CRS‐care …

Dupilumab‐induced eosinophilia in patients with diffuse type 2 chronic rhinosinusitis

FS Ryser, A Yalamanoglu, A Valaperti, C Brühlmann… - Allergy, 2023 - Wiley Online Library
Background Dupilumab, a monoclonal anti‐IL‐4Rα antibody, is approved for several type 2
mediated inflammatory diseases like asthma, atopic dermatitis, and diffuse type 2 chronic …

[HTML][HTML] Eosinophilic granulomatosis with polyangiitis developed after dupilumab administration in patients with eosinophilic chronic rhinosinusitis and asthma: a case …

I Suzaki, A Tanaka, R Yanai, Y Maruyama… - BMC Pulmonary …, 2023 - Springer
Background Eosinophilic granulomatosis with polyangiitis (EGPA) is a form of anti-
neutrophil cytoplasmic antibody (ANCA) associated vasculitis characterized by eosinophil …

[HTML][HTML] How can dupilumab cause eosinophilic pneumonia?

M Kurihara, K Masaki, E Matsuyama, M Fujioka… - Biomolecules, 2022 - mdpi.com
Reports of eosinophilic pneumonia (EP) as a side effect of dupilumab administration are
limited in previous studies. Herein, we report two cases in which EP developed subsequent …

[HTML][HTML] The Possible Roles of IL-4/IL-13 in the Development of Eosinophil-Predominant Severe Asthma

K Nakagome, M Nagata - Biomolecules, 2024 - mdpi.com
Bronchial asthma is characterized by airway inflammation, airway hyperresponsiveness,
and reversible airway obstruction. Eosinophils contribute to the pathogenesis of airway …

[HTML][HTML] Monoclonal antibodies in idiopathic chronic eosinophilic pneumonia: a scoping review

AD Murillo, AI Castrillon, CD Serrano… - BMC Pulmonary …, 2024 - Springer
Background Idiopathic chronic eosinophilic pneumonia (ICEP) is a rare disease
characterized by pulmonary radiological alterations, peripheral eosinophilia, and …

Dupilumab and the potential risk of eosinophilic pneumonia: case report, literature review, and FAERS database analysis

X Zhou, G Yang, X Zeng, L Wang, J Xiang… - Frontiers in …, 2024 - frontiersin.org
Eosinophilic pneumonia (EP) is a rare but noteworthy adverse effect linked to dupilumab, an
interleukin-4 (IL-4) and IL-13 inhibitor used in the managing atopic diseases. The underlying …

Eosinophilic pneumonia developed after dupilumab administration in a patient with atopic dermatitis

K Kanata, T Shirai, K Ichijo… - Respirology Case …, 2023 - Wiley Online Library
A 63‐year‐old woman with refractory atopic dermatitis started treatment with dupilumab. She
developed a cough 4 days later, sputum, and a slight fever 2 weeks later. Laboratory test …