Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …

Coding variants in apolipoprotein L1 (APOL1), termed G1 and G2, can explain most excess
kidney disease risk in African Americans; however, the molecular pathways of APOL1 …

Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Although diabetic kidney disease (DKD) is the most common cause of end-stage kidney
disease worldwide, the pathogenic mechanisms are poorly understood. There is increasing …

The kidney has a remarkable ability of repair after acute kidney injury (AKI). However, when
injury is severe or persistent, the repair is incomplete or maladaptive and may lead to …

Chronic kidney disease (CKD) is associated with a higher risk of atrial fibrillation (AF). The
mechanistic link between CKD and AF remains elusive. IL-1β, a main effector of NLR family …

Cytoplasmic nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
forms an inflammasome with apoptosis-associated speck-like protein containing a CARD …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are worldwide public health
problems affecting millions of people and have rapidly increased in prevalence in recent …