Simple Summary Human health is significantly affected by microbial infections. One of the
largest determinants of the outcomes of such infections is the host immune response. Too …

Anopheles stephensi, an Asian malaria vector, continues to expand across Africa. The
vector is now firmly established in urban settings in the Horn of Africa. Its presence in areas …

Background Symptomatic malaria cases reflect only a small proportion of all Plasmodium
spp infections. Many infected individuals are asymptomatic, and persistent asymptomatic …

HighlightsSpontaneous clearance of P. falciparum infections in the absence of antimalarial
drug treatment has been demonstrated in a range of transmission settings and confirmed by …

Background Routine malaria surveillance data in Africa primarily come from public health
facilities reporting to national health management information systems. Although information …

Malaria transmission depends on the presence of Plasmodium gametocytes that are the
only parasite life stage that can infect mosquitoes. Gametocyte production varies between …

Abstract Background Adults infected with Plasmodium spp. in endemic areas need to be re-
evaluated in light of global malaria elimination goals. They potentially undermine malaria …

Background Schoolchildren with asymptomatic malaria infections often go undiagnosed and
untreated, serving as reservoirs for infection that hamper malaria control and elimination …

Natural immunity to malaria develops over time with repeated malaria episodes, but
protection against severe malaria and immune regulation limiting immunopathology, called …

Background The gold standard for diagnosing Plasmodium falciparum infection is
microscopic examination of Giemsa-stained peripheral blood smears. The effectiveness of …