Cystic fibrosis: a review
T Ong, BW Ramsey - Jama, 2023 - jamanetwork.com
Importance Cystic fibrosis, a genetic disorder defined by variants in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene, affects more than 30 000 individuals in …
transmembrane conductance regulator (CFTR) gene, affects more than 30 000 individuals in …
[HTML][HTML] Physicochemical properties of mucus and their impact on transmucosal drug delivery
Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …
[HTML][HTML] ESCMID guideline for the diagnosis and treatment of biofilm infections 2014
Biofilms cause chronic infections in tissues or by developing on the surfaces of medical
devices. Biofilm infections persist despite both antibiotic therapy and the innate and adaptive …
devices. Biofilm infections persist despite both antibiotic therapy and the innate and adaptive …
[HTML][HTML] European cystic fibrosis society standards of care: best practice guidelines
Specialised CF care has led to a dramatic improvement in survival in CF: in the last four
decades, well above what was seen in the general population over the same period. With …
decades, well above what was seen in the general population over the same period. With …
Applying insights from biofilm biology to drug development—can a new approach be developed?
Most of the research on bacterial pathogenesis has focused on acute infections, but much
less is known about the pathogenesis of infections caused by bacteria that grow as …
less is known about the pathogenesis of infections caused by bacteria that grow as …
What the pulmonary specialist should know about the new inhalation therapies
BL Laube, HM Janssens, FHC de Jongh… - 2011 - Eur Respiratory Soc
A collaboration of multidisciplinary experts on the delivery of pharmaceutical aerosols was
facilitated by the European Respiratory Society (ERS) and the International Society for …
facilitated by the European Respiratory Society (ERS) and the International Society for …
[HTML][HTML] Treatment of lung infection in patients with cystic fibrosis: current and future strategies
In patients with cystic fibrosis (CF) lung damage secondary to chronic infection is the main
cause of death. Treatment of lung disease to reduce the impact of infection, inflammation …
cause of death. Treatment of lung disease to reduce the impact of infection, inflammation …
[HTML][HTML] Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms
M Fernández-Billón, AE Llambías-Cabot… - Biofilm, 2023 - Elsevier
Pseudomonas aeruginosa is a major cause of life-threatening acute infections and life-long
lasting chronic infections. The characteristic biofilm mode of life in P. aeruginosa chronic …
lasting chronic infections. The characteristic biofilm mode of life in P. aeruginosa chronic …
Inhaled antibiotics for lower airway infections
BS Quon, CH Goss, BW Ramsey - Annals of the American Thoracic …, 2014 - atsjournals.org
Inhaled antibiotics have been used to treat chronic airway infections since the 1940s. The
earliest experience with inhaled antibiotics involved aerosolizing antibiotics designed for …
earliest experience with inhaled antibiotics involved aerosolizing antibiotics designed for …
Safety, efficacy and convenience of colistimethate sodium dry powder for inhalation (Colobreathe DPI) in patients with cystic fibrosis: a randomised study
A Schuster, C Haliburn, G Döring, MH Goldman… - Thorax, 2013 - thorax.bmj.com
Purpose To assess efficacy and safety of a new dry powder formulation of inhaled
colistimethate sodium in patients with cystic fibrosis (CF) aged≥ 6 years with chronic …
colistimethate sodium in patients with cystic fibrosis (CF) aged≥ 6 years with chronic …