Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …

The assembly of HIV-1 particles is a concerted and dynamic process that takes place on the
plasma membrane of infected cells. An abundance of recent discoveries has advanced our …

HIV-1 selectively packages two copies of its 5′-capped RNA genome (gRNA) during virus
assembly, a process mediated by the nucleocapsid (NC) domain of the viral Gag polyprotein …

Two non-covalently linked copies of the retrovirus genome are specifically recruited to the
site of virus particle assembly and packaged into released particles. Retroviral RNA …

Recent advances in the study of virus-cell interactions have improved our understanding of
how viruses that replicate their genomes in the nucleus (eg, retroviruses, hepadnaviruses …

Viruses remain a global threat to animals, plants, and humans. The type 1 human
immunodeficiency virus (HIV-1) is a member of the retrovirus family and carries an RNA …

HIV-1 infection remains non-curative due to the latent reservoir, primarily a small pool of
resting memory CD4+ T cells bearing replication-competent provirus. Pharmacological …

RNA viruses and viroids replicate with high mutation rates, forming quasispecies, population
of variants centered around dominant sequences. The mechanisms governing quasispecies …

A cure for HIV-1 (HIV) remains unrealized due to a reservoir of latently infected cells that
persist during antiretroviral therapy (ART), with reservoir size associated with adverse health …