The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

The glymphatic system is a fluid-transport system that accesses all regions of the brain. It
facilitates the exchange of cerebrospinal fluid and interstitial fluid and clears waste from the …

Meningeal lymphatic vessels have been described in animal studies, but limited comparable
data is available in human studies. Here we show dural lymphatic structures along the dural …

Meningeal lymphatic vessels (MLVs) were identified in the dorsal and caudobasal regions of
the dura mater, where they ensure waste product elimination and immune surveillance of …

Alpha-synucleinopathy is postulated to be central to both idiopathic rapid eye movement
sleep behaviour disorder (iRBD) and Parkinson's disease (PD). Growing evidence suggests …

For the last two decades, pathogenic concepts in Parkinson disease (PD) have revolved
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …

The brain glymphatic system is involved in the clearance of misfolding α-synuclein, the
impaired glymphatic system may contribute to the progression of Parkinson's disease (PD) …

The meningeal lymphatic network enables the drainage of cerebrospinal fluid (CSF) and
facilitates the removal of central nervous system (CNS) waste. During aging and in …

Cerebral amyloid angiopathy (CAA) is a common disease in older adults that contributes to
dementia,–. In CAA, amyloid beta (Aβ) is deposited along either capillaries (type 1) or vessel …

The recent discovery of lymphatic vessels (LVs) in the dura mater, the outermost layer of
meninges around the central nervous system (CNS), has opened a possibility for the …