[HTML][HTML] Unlocking the promise of mRNA therapeutics
E Rohner, R Yang, KS Foo, A Goedel… - Nature biotechnology, 2022 - nature.com
The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19)
has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical …
has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical …
[HTML][HTML] Targeting circular RNAs as a therapeutic approach: current strategies and challenges
Significant progress has been made in circular RNA (circRNA) research in recent years.
Increasing evidence suggests that circRNAs play important roles in many cellular processes …
Increasing evidence suggests that circRNAs play important roles in many cellular processes …
Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines
Circular RNAs (circRNA) is a class of natural (biogenic) or synthetic closed RNA without 5′
or 3′ ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA …
or 3′ ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA …
RNA drugs and RNA targets for small molecules: principles, progress, and challenges
RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
Role of circular RNAs in brain development and CNS diseases
In mammals, many classes of noncoding RNAs (ncRNAs) are expressed at a much higher
level in the brain than in other organs. Recent studies have identified a new class of ncRNAs …
level in the brain than in other organs. Recent studies have identified a new class of ncRNAs …
Preclinical and clinical development of noncoding RNA therapeutics for cardiovascular disease
RNA modulation has become a promising therapeutic approach for the treatment of several
types of disease. The emerging field of noncoding RNA-based therapies has now come to …
types of disease. The emerging field of noncoding RNA-based therapies has now come to …
CircRNA cRAPGEF5 inhibits the growth and metastasis of renal cell carcinoma via the miR-27a-3p/TXNIP pathway
Q Chen, T Liu, YI Bao, T Zhao, J Wang, H Wang… - Cancer letters, 2020 - Elsevier
Circular RNAs (circRNAs) are reported to act as important regulators in cancers. CircRNA
RAPGEF5 (cRAPGEF5) is derived from exons 2–6 of the RAPGEF5 gene and may promote …
RAPGEF5 (cRAPGEF5) is derived from exons 2–6 of the RAPGEF5 gene and may promote …
[HTML][HTML] Circular RNAs: expression, localization, and therapeutic potentials
Circular RNAs (circRNAs) are RNAs with a unique circular structure that is generated from
back-splicing processes. These circular molecules were discovered more than 40 years ago …
back-splicing processes. These circular molecules were discovered more than 40 years ago …
A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity
D Lu, S Chatterjee, K Xiao, I Riedel… - European heart …, 2022 - academic.oup.com
Aims Cardiotoxicity leading to heart failure (HF) is a growing problem in many cancer
survivors. As specific treatment strategies are not available, RNA discovery pipelines were …
survivors. As specific treatment strategies are not available, RNA discovery pipelines were …
Synthetic circular RNA switches and circuits that control protein expression in mammalian cells
S Kameda, H Ohno, H Saito - Nucleic acids research, 2023 - academic.oup.com
Synthetic messenger RNA (mRNA) has been focused on as an emerging application for
mRNA-based therapies and vaccinations. Recently, synthetic circular RNAs (circRNAs) …
mRNA-based therapies and vaccinations. Recently, synthetic circular RNAs (circRNAs) …