Methylation across the central dogma in health and diseases: new therapeutic strategies
R Liu, E Zhao, H Yu, C Yuan, MN Abbas… - Signal Transduction and …, 2023 - nature.com
The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …
[HTML][HTML] Novel insights into the interplay between m6A modification and programmed cell death in cancer
J Chen, M Ye, J Bai, C Hu, F Lu, D Gu… - International journal of …, 2023 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) methylation, the most prevalent and abundant RNA
modification in eukaryotes, has recently become a hot research topic. Several studies have …
modification in eukaryotes, has recently become a hot research topic. Several studies have …
FTO-Nrf2 axis regulates bisphenol F-induced leydig cell toxicity in an m6A-YTHDF2-dependent manner
S Zhou, J Li, H Chen, Y Zeng, W Yuan, Y Shi… - Environmental …, 2023 - Elsevier
Studies have shown that Bisphenol F (BPF) as an emerging bisphenol pollutant also has
caused many hazards to the reproductive systems of humans and animals. However, its …
caused many hazards to the reproductive systems of humans and animals. However, its …
Epigenetic regulation and therapeutic targets in the tumor microenvironment
Z Xie, Z Zhou, S Yang, S Zhang, B Shao - Molecular Biomedicine, 2023 - Springer
The tumor microenvironment (TME) is crucial to neoplastic processes, fostering proliferation,
angiogenesis and metastasis. Epigenetic regulations, primarily including DNA and RNA …
angiogenesis and metastasis. Epigenetic regulations, primarily including DNA and RNA …
[HTML][HTML] Experimental validation and pan-cancer analysis identified COL10A1 as a novel oncogene and potential therapeutic target in prostate cancer
S Xu, D Liu, Z Qin, Z Liang, H Xie, B Yi, K Wang… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Background: Type X collagen (COL10) is a homologous trimeric non-fibrillar collagen found
in the extracellular matrix of human tissues, and it exhibits a distinctive white appearance …
in the extracellular matrix of human tissues, and it exhibits a distinctive white appearance …
Crosstalk between cancer-associated fibroblasts and regulated cell death in tumors: insights into apoptosis, autophagy, ferroptosis, and pyroptosis
C Chen, J Liu, X Lin, A Xiang, Q Ye, J Guo, T Rui… - Cell Death …, 2024 - nature.com
Abstract Cancer-associated fibroblasts (CAFs), the main stromal component of the tumor
microenvironment (TME), play multifaceted roles in cancer progression through paracrine …
microenvironment (TME), play multifaceted roles in cancer progression through paracrine …
The RNA m6A writer METTL3 in tumor microenvironment: emerging roles and therapeutic implications
W Su, L Che, W Liao, H Huang - Frontiers in Immunology, 2024 - frontiersin.org
The tumor microenvironment (TME) is a heterogeneous ecosystem comprising cancer cells,
immune cells, stromal cells, and various non-cellular components, all of which play critical …
immune cells, stromal cells, and various non-cellular components, all of which play critical …
[HTML][HTML] METTL3-m6A methylation inhibits the proliferation and viability of type II alveolar epithelial cells in acute lung injury by enhancing the stability and translation …
Q Wang, J Shen, S Luo, Z Yuan, S Wei, Q Li… - Respiratory …, 2024 - ncbi.nlm.nih.gov
Background The pathogenesis of acute lung injury (ALI) involves a severe inflammatory
response, leading to significant morbidity and mortality. N6-methylation of adenosine (m6A) …
response, leading to significant morbidity and mortality. N6-methylation of adenosine (m6A) …
[HTML][HTML] Differential roles of normal and lung cancer-associated fibroblasts in microvascular network formation
Perfusable microvascular networks offer promising three-dimensional in vitro models to
study normal and compromised vascular tissues as well as phenomena such as cancer cell …
study normal and compromised vascular tissues as well as phenomena such as cancer cell …
[HTML][HTML] Association between methyltransferase-like 3 and non-small cell lung cancer: pathogenesis, therapeutic resistance, and clinical applications
X Su, Y Feng, Y Qu, D Mu - Translational Lung Cancer Research, 2024 - ncbi.nlm.nih.gov
Non-small cell lung cancer (NSCLC) is a malignant cancer that with high incidence,
recurrence, and mortality rates in human beings, posing significant threats to human health …
recurrence, and mortality rates in human beings, posing significant threats to human health …