Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …

Approximately one-tenth of the general population exhibit adrenal cortical nodules, and the
incidence has increased. Afflicted patients display a multifaceted symptomatology …

Abstract N6-methyladenosine (m6A), internal modification of mRNA, has recently been
reported to be an important regulatory mechanism affecting tumor proliferation. However, its …

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy arising from the adrenal
cortex often with unexpected biological behavior. It can occur at any age, with two peaks of …

Background After radical resection, patients with adrenocortical carcinoma (ACC) frequently
experience recurrence and, therefore, effective adjuvant treatment is urgently needed. The …

International guidelines emphasise the role of local therapies (LT) for the treatment of
advanced adrenocortical carcinoma (ACC). However, large studies are lacking in this field …

Being a rare malignancy, adrenocortical carcinoma (ACC) exhibits aggressiveness and poor
prognosis. Fibronectin type III domain‑containing protein 5 (FNDC5) is a transmembrane …

Background The prognosis of adrenocortical carcinoma (ACC) is poor but highly variable.
The present study aimed to characterize patients with ACC at a single center in Taiwan and …

Background Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with a
poor prognosis. Given the limited treatment options, prognostic assessment of ACC is …

Objective To evaluate the performance characteristics of AJCC 7th and 8th staging systems
among patients with adrenal cortical carcinoma. Methods Surveillance, Epidemiology, and …