The Biotechnological “Provence” of the Future Provided by Antisense Oligoilators and Olinscides for Horticulturae

VV Oberemok, YV Puzanova, IA Novikov - Horticulturae, 2023 - mdpi.com
Successful management of the synthesis of secondary metabolites of essential oil plants is
the basis for the economic growth of the essential oil industry. Against the backdrop of a …

Redox modulating small molecules having antimalarial efficacy

C Pal - Biochemical Pharmacology, 2023 - Elsevier
The search for effective antimalarial agents remains a critical priority because malaria is
widely spread and drug-resistant strains are becoming more prevalent. In this review, a …

[HTML][HTML] Palmitoylation of PKCδ by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease

YH Wang, X Chen, YZ Bai, P Gao, Z Yang, Q Guo… - Theranostics, 2024 - ncbi.nlm.nih.gov
The hypothalamus plays a fundamental role in controlling lipid metabolism through
neuroendocrine signals. However, there are currently no available drug targets in the …

MADS-box gene AaSEP4 promotes artemisinin biosynthesis in Artemisia annua

TT Chen, XH Yao, H Liu, YP Li, W Qin, X Yan… - Frontiers in Plant …, 2022 - frontiersin.org
The plant Artemisia annua is well known for its production of artemisinin, a sesquiterpene
lactone that is an effective antimalarial compound. Although remarkable progress has been …

Dihydroartemisinin engages liver fatty acid binding protein and suppresses metastatic hepatocellular carcinoma growth

ML Ruan, Y Liu, C Zhang, X Mao, D Hu… - Chemical …, 2023 - pubs.rsc.org
Dihydroartemisinin engages liver fatty acid binding protein and suppresses metastatic
hepatocellular carcinoma growth - Chemical Communications (RSC Publishing) DOI:10.1039/D3CC00265A …

Chemical and spectroscopic characterization of (Artemisinin/Querctin/Zinc) novel mixed ligand complex with assessment of its potent high antiviral activity against …

SM El-Megharbel, SH Qahl, B Albogami, RZ Hamza - PeerJ, 2024 - peerj.com
Abstract A novel Artemisinin/Quercetin/Zinc (Art/Q/Zn) mixed ligand complex was
synthesized, tested for its antiviral activity against coronavirus (SARS-CoV-2), and …

Synthesis and spectroscopic study of novel mixed ligand formula “Artemisinin/Zn” and assessment of its inhibitory effect against “SARS-CoV-2 ″

FA Al-Salmi, SM El-Megharbel, RZ Hamza - Heliyon, 2023 - cell.com
Background Herein, a newly synthesised mixed ligand artemisinin/zinc (Art/Zn) is chemically
characterised and examined against SARS-CoV-2. Methods The synthesised complex was …

TPN10475 alleviates concanavalin A-induced autoimmune hepatitis by limiting T cell development and function through inhibition of PI3K-AKT pathway

C Wang, M Han, X Li, J Lv, W Zhuang, L Xie… - International …, 2023 - Elsevier
Autoimmune hepatitis (AIH) is an inflammatory liver disease in which the autoimmune
system instigates an attack on the liver, causing inflammation and liver injury, and its …

Applicability of Redirecting Artemisinins for New Targets

J Golenser, NH Hunt, I Birman, CL Jaffe… - Global …, 2023 - Wiley Online Library
Employing new therapeutic indications for drugs that are already approved for human use
has obvious advantages, including reduced costs and timelines, because some routine …

Exploring the potential of aqueous extracts of Artemisia annua ANAMED (A3) for developing new anti‐malarial agents: In vivo and silico computational approach

VO Apeh, KC Okafor, IF Chukwuma… - Engineering …, 2023 - Wiley Online Library
The emergence of resistance to current antimalarial drugs poses a significant challenge in
the fight against malaria. This study aimed to investigate the in vivo antiplasmodial potential …