Poor retention rate, low targeting accuracy, and spontaneous transformation of stem cells
present major clinical barriers to the success of therapies based on stem cell transplantation …

This review focuses on current tissue engineering strategies for promoting vascularized
bone regeneration. We review the role of angiogenic growth factors in promoting …

Mesenchymal stem cell (MSC) therapies demonstrate particular promise in ameliorating
diseases of immune dysregulation but are hampered by short in vivo cell persistence and …

Osteoarthritis (OA) is the most common form of degenerative arthritis, mainly characterized
by the degradation of articular cartilage and associated with subchondral bone lesions …

Summary 2018 was the year of the first marketing authorization of an allogeneic stem cell
therapy by the European Medicines Agency. The authorization concerns the use of …

The treatment of cancer was revolutionized within the last two decades by utilizing the
mechanism of the immune system against malignant tissue in so-called cancer …

Mesenchymal stromal cell (MSC) therapies have been pursued for a broad spectrum of
indications but mixed reports on clinical efficacy have given rise to some degree of …

Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by three
core symptoms that include social interaction deficits, cognitive inflexibility, and …

Stem cell-based therapies are emerging as a promising strategy to tackle cancer. Multiple
stem cell types have been shown to exhibit inherent tropism towards tumours. Moreover …

Abstract Background Extracellular vesicles (EVs) produced by human bone marrow-derived
mesenchymal stromal cells (hBM-MSCs) are currently investigated for their clinical …