Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Fibroblast growth factor 21 (FGF21) is a peptide hormone that is synthesized by several
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …

The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for
maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism …

The discovery of the Klotho (KL) gene, which was originally identified as a putative aging-
suppressor gene, has generated tremendous interest and has advanced understanding of …

Summary Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects
on regulating glucose and lipid homeostasis and insulin sensitivity. However, the …

Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …

Abstract Fibroblast growth factor 21 (FGF21) is a hepatokine that acts as a global starvation
signal to modulate fuel partitioning and metabolism and repress growth; however, the site of …

Fibroblast growth factors (FGFs) mediate a broad range of functions in both the developing
and adult organism. The accumulated wealth of structural information on the FGF signalling …

FGF21, a member of the fibroblast growth factor (FGF) superfamily, has recently emerged as
a regulator of metabolism and energy utilization. However, the exact mechanism (s) …