Catalytic properties and biomedical applications of cerium oxide nanoparticles

C Walkey, S Das, S Seal, J Erlichman… - Environmental …, 2015 - pubs.rsc.org
Cerium oxide nanoparticles (nanoceria) have shown promise as catalytic antioxidants in the
test tube, cell culture models and animal models of disease. However given the reactivity …

Animal models of multiple sclerosis

C Procaccini, V De Rosa, V Pucino, L Formisano… - European journal of …, 2015 - Elsevier
Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) which involves a complex interaction between immune system and neural …

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

JK Ryu, MA Petersen, SG Murray, KM Baeten… - Nature …, 2015 - nature.com
Autoimmunity and macrophage recruitment into the central nervous system (CNS) are
critical determinants of neuroinflammatory diseases. However, the mechanisms that drive …

Synaptopathy connects inflammation and neurodegeneration in multiple sclerosis

G Mandolesi, A Gentile, A Musella… - Nature Reviews …, 2015 - nature.com
Multiple sclerosis (MS) has long been regarded as a chronic inflammatory disease of the
white matter that leads to demyelination and eventually to neurodegeneration. In the past …

The neuroprotective functions of transforming growth factor beta proteins

A Dobolyi, C Vincze, G Pál, G Lovas - International journal of molecular …, 2012 - mdpi.com
Transforming growth factor beta (TGF-β) proteins are multifunctional cytokines whose neural
functions are increasingly recognized. The machinery of TGF-β signaling, including the …

[HTML][HTML] The multifactorial role of the 3Rs in shifting the harm-benefit analysis in animal models of disease

ML Graham, MJ Prescott - European Journal of Pharmacology, 2015 - Elsevier
Ethics on animal use in science in Western society is based on utilitarianism, weighing the
harms and benefits to the animals involved against those of the intended human …

Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration

RD Spence, RR Voskuhl - Frontiers in neuroendocrinology, 2012 - Elsevier
Multiple sclerosis (MS) is a disease characterized by inflammation and demyelination.
Currently, the cause of MS is unknown. Experimental autoimmune encephalomyelitis (EAE) …

Modeling neurodegenerative disorders in zebrafish

AA Bashirzade, KN Zabegalov, AD Volgin… - Neuroscience & …, 2022 - Elsevier
Neurodegeneration is a major cause of Alzheimer's, Parkinson's, Huntington's, multiple and
amyotrophic lateral sclerosis, pontocerebellar hypoplasia, dementia and other related brain …

[HTML][HTML] Diversity of reactive astrogliosis in CNS pathology: heterogeneity or plasticity?

AJ Moulson, JW Squair, RJM Franklin… - Frontiers in cellular …, 2021 - frontiersin.org
Astrocytes are essential for the development and homeostatic maintenance of the central
nervous system (CNS). They are also critical players in the CNS injury response during …

Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by …

Z Salehipour, D Haghmorad, M Sankian… - Biomedicine & …, 2017 - Elsevier
Abstract Background Multiple Sclerosis (MS) is a chronic inflammatory autoimmune disease
of the central nervous system (CNS). Recent reports have shown that probiotics can induce …