Therapeutic targeting of the immune system in cancer is now a clinical reality and marked
successes have been achieved, most notably through the use of checkpoint blockade …

The therapeutic effect of highly malignant triple negative breast cancer (TNBC) is negatively
affected by the formation of tumor cell resistant clone and the severe toxicity of …

Cancer has complex pathophysiology and is one of the primary causes of death and
morbidity across the world. Chemotherapy, targeted therapy, radiation therapy, and …

Vaccines are one of the most powerful technologies supporting public health. The adaptive
immune response induced by immunization arises following appropriate activation and …

Personalized cancer vaccines (PCVs) are reinvigorating vaccine strategies in cancer
immunotherapy. In contrast to adoptive T-cell therapy and checkpoint blockade, the PCV …

Developing non‐cationic gene carriers and achieving efficient endo/lysosome escape of
functional nucleic acids in cytosol are two major challenges faced by the field of gene …

Highly heterogenous cancers, such as triple-negative breast cancer (TNBC), remain
challenging immunotherapeutic targets. Herein, we describe the synthesis and evaluation of …

The clinical performance of conventional cancer therapy approaches (surgery, radiotherapy,
and chemotherapy) has been challenged by tumor metastasis and recurrence that is mainly …

Herein, we developed hybrid DNAzyme nanoparticles (NPs) to achieve light-induced carrier-
free self-delivery of DNAzymes with sufficient cofactor supply and lysosome escape …

Therapeutic oligonucleotides (TOs) represent one of the most promising drug candidates in
the targeted cancer treatment due to their high specificity and capability of modulating …