[HTML][HTML] Considerations and challenges in studying liquid-liquid phase separation and biomolecular condensates
Evidence is now mounting that liquid-liquid phase separation (LLPS) underlies the formation
of membraneless compartments in cells. This realization has motivated major efforts to …
of membraneless compartments in cells. This realization has motivated major efforts to …
Protein phase separation: a new phase in cell biology
Cellular compartments and organelles organize biological matter. Most well-known
organelles are separated by a membrane boundary from their surrounding milieu. There are …
organelles are separated by a membrane boundary from their surrounding milieu. There are …
ATPase-modulated stress granules contain a diverse proteome and substructure
Stress granules are mRNA-protein granules that form when translation initiation is limited,
and they are related to pathological granules in various neurodegenerative diseases. Super …
and they are related to pathological granules in various neurodegenerative diseases. Super …
Distinct stages in stress granule assembly and disassembly
Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when
translation initiation is limited and contain a biphasic structure with stable core structures …
translation initiation is limited and contain a biphasic structure with stable core structures …
Stress-and ubiquitylation-dependent phase separation of the proteasome
S Yasuda, H Tsuchiya, A Kaiho, Q Guo, K Ikeuchi… - Nature, 2020 - nature.com
The proteasome is a major proteolytic machine that regulates cellular proteostasis through
selective degradation of ubiquitylated proteins,. A number of ubiquitin-related molecules …
selective degradation of ubiquitylated proteins,. A number of ubiquitin-related molecules …
Polymer physics of intracellular phase transitions
Intracellular organelles are either membrane-bound vesicles or membrane-less
compartments that are made up of proteins and RNA. These organelles play key biological …
compartments that are made up of proteins and RNA. These organelles play key biological …
Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases
Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
C9orf72 dipeptide repeats impair the assembly, dynamics, and function of membrane-less organelles
Expansion of a hexanucleotide repeat GGGGCC (G 4 C 2) in C9ORF72 is the most common
cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Transcripts …
cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Transcripts …
[HTML][HTML] The control centers of biomolecular phase separation: how membrane surfaces, PTMs, and active processes regulate condensation
WT Snead, AS Gladfelter - Molecular cell, 2019 - cell.com
Biomolecular condensation is emerging as an essential process for cellular
compartmentalization. The formation of biomolecular condensates can be driven by liquid …
compartmentalization. The formation of biomolecular condensates can be driven by liquid …
Sequence determinants of intracellular phase separation by complex coacervation of a disordered protein
Liquid-liquid phase separation, driven by collective interactions among multivalent and
intrinsically disordered proteins, is thought to mediate the formation of membrane-less …
intrinsically disordered proteins, is thought to mediate the formation of membrane-less …