Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2023 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

[HTML][HTML] Epithelial–Mesenchymal Transition Mechanisms in Chronic Airway Diseases: A Common Process to Target?

A Mottais, L Riberi, A Falco, S Soccal, S Gohy… - International journal of …, 2023 - mdpi.com
Epithelial-to-mesenchymal transition (EMT) is a reversible process, in which epithelial cells
lose their epithelial traits and acquire a mesenchymal phenotype. This transformation has …

Assessing the efficacy of fenugreek saponin nanoparticles in attenuating nicotine-induced hepatotoxicity in male rats

KA Hamed, SA El-Fiky, AM Gawish… - ACS …, 2023 - ACS Publications
During smoking, nicotine, the most bountiful compound in cigarettes, is absorbed into the
body by the lungs and quickly metabolized in the liver, causing three major adverse impacts …

A Conformable Organic Electronic Device for Monitoring Epithelial Integrity at the Air Liquid Interface

SL Barron, SV Oldroyd, J Saez, A Chernaik… - Advanced …, 2024 - Wiley Online Library
Air liquid interfaced (ALI) epithelial barriers are essential for homeostatic functions such as
nutrient transport and immunological protection. Dysfunction of such barriers are implicated …

[HTML][HTML] Electronic cigarette exposure increases the severity of influenza a virus infection via TRAIL dysregulation in human precision-cut lung slices

H Agraval, T Crue, N Schaunaman, M Numata… - International Journal of …, 2023 - mdpi.com
The use of electronic nicotine dispensing systems (ENDS), also known as electronic
cigarettes (ECs), is common among adolescents and young adults with limited knowledge …

[HTML][HTML] Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 …

Z Zhao, Z Xu, J Chang, L He, Z Zhang, X Song… - Journal of …, 2023 - Springer
Background Ferroptosis in alveolar and bronchial epithelial cells is one of the main
mechanisms underlying the development of chronic obstructive pulmonary disease (COPD) …

Epithelial–mesenchymal transition changes in nonsmall cell lung cancer patients with early COPD

W Lu, MS Eapen, A Hardikar, C Chia… - ERJ Open …, 2023 - Eur Respiratory Soc
Background Epithelial–mesenchymal transition (EMT) might be central to lung cancer
development in smokers and COPD. We illustrate EMT changes in a broader demographic …

Efficacy and Mechanisms of Natural Products as Therapeutic Interventions for Chronic Respiratory Diseases

F Jin, P Fan, Y Wu, Q Yang, J Li, H Liu - The American Journal of …, 2024 - World Scientific
Chronic respiratory diseases are long-term conditions affecting the airways and other lung
components that are characterized by a high prevalence, disability rate, and mortality rate …

MMPs as potential molecular target in epithelial-to-mesenchymal transition driven COPD progression

H Agraval, K Kandhari, UCS Yadav - Life Sciences, 2024 - Elsevier
Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality
globally and the risk of developing lung cancer is six times greater in individuals with COPD …

Fecal microbiome extract downregulates the expression of key proteins at the interface between airway remodelling and lung cancer pathogenesis in vitro

G De Rubis, KR Paudel, S Vishwas, S Kokkiniks… - … -Research and Practice, 2024 - Elsevier
Lung cancer (LC) is the leading cause of cancer-related mortality, and it is caused by many
factors including cigarette smoking. Despite numerous treatment strategies for LC, its five …