Insights into the mechanisms involved in the expression and regulation of extracellular matrix proteins in diabetic nephropathy
C Hu, L Sun, L Xiao, Y Han, X Fu… - Current medicinal …, 2015 - ingentaconnect.com
Diabetic Nephropathy (DN) is believed to be a major microvascular complication of
diabetes. The hallmark of DN includes deposition of Extracellular Matrix (ECM) proteins …
diabetes. The hallmark of DN includes deposition of Extracellular Matrix (ECM) proteins …
[HTML][HTML] The novel Rho kinase (ROCK) inhibitor K-115: a new candidate drug for neuroprotective treatment in glaucoma
K Yamamoto, K Maruyama, N Himori… - … & visual science, 2014 - tvst.arvojournals.org
Purpose.: To investigate the effect of K-115, a novel Rho kinase (ROCK) inhibitor, on retinal
ganglion cell (RGC) survival in an optic nerve crush (NC) model. Additionally, to determine …
ganglion cell (RGC) survival in an optic nerve crush (NC) model. Additionally, to determine …
Anti-fibrosis therapy and diabetic nephropathy
A Karihaloo - Current diabetes reports, 2012 - Springer
Diabetes mellitus is rapidly becoming a global health issue that may overtake cancer during
the next two decades as it covertly affects multiple organ systems that goes undiagnosed …
the next two decades as it covertly affects multiple organ systems that goes undiagnosed …
Diabetes causes bone marrow endothelial barrier dysfunction by activation of the RhoA–Rho-associated kinase signaling pathway
G Mangialardi, R Katare, A Oikawa… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—Diabetes mellitus causes bone marrow (BM) microangiopathy. This study aimed
to investigate the mechanisms responsible for BM endothelial dysfunction in diabetes …
to investigate the mechanisms responsible for BM endothelial dysfunction in diabetes …
Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-κB signaling pathway activation in vascular endothelial cells
D Kawanami, K Matoba, Y Kanazawa… - Biochemical and …, 2011 - Elsevier
Thrombin has been shown to increase expression of chemokines such as monocyte
chemoattractant protein 1 (MCP-1) in endothelial cells, leading to the development of …
chemoattractant protein 1 (MCP-1) in endothelial cells, leading to the development of …
Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling
A Nguyen Dinh Cat, GE Callera… - Scientific Reports, 2018 - nature.com
Activation of aldosterone/mineralocorticoid receptors (MR) has been implicated in vascular
dysfunction of diabetes. Underlying mechanisms are elusive. Therefore, we investigated the …
dysfunction of diabetes. Underlying mechanisms are elusive. Therefore, we investigated the …
Early progression of the autonomic dysfunction observed in pediatric type 1 diabetes mellitus
D Lucini, G Zuccotti, M Malacarne, A Scaramuzza… - …, 2009 - Am Heart Assoc
To focus on early cardiac and vascular autonomic dysfunction that might complicate type 1
diabetes mellitus in children, we planned an observational, cross-sectional study in a …
diabetes mellitus in children, we planned an observational, cross-sectional study in a …
[HTML][HTML] Inhibition of retinal ganglion cell loss by a novel ROCK inhibitor (E212) in ischemic optic nerve injury via antioxidative and anti-inflammatory actions
YT Wen, CW Huang, CP Liu, CH Chen… - … & Visual Science, 2021 - arvojournals.org
Purpose: This study investigated the neuroprotective effects of administration of ROCK
inhibitor E212 on ischemic optic neuropathy. Methods: Rats received an intravitreal injection …
inhibitor E212 on ischemic optic neuropathy. Methods: Rats received an intravitreal injection …
The protective effect of fasudil on the structure and function of cardiac mitochondria from rats with type 2 diabetes induced by streptozotocin with a high‐fat diet is …
R Guo, B Liu, S Zhou, B Zhang… - BioMed Research …, 2013 - Wiley Online Library
Dysfunction of cardiac mitochondria appears to play a substantial role in cardiomyopathy or
myocardial dysfunction and is a promising therapeutic target for many cardiovascular …
myocardial dysfunction and is a promising therapeutic target for many cardiovascular …
Rho‐kinase inhibitor Y‐27632 increases cellular proliferation and migration in human foreskin fibroblast cells
J Piltti, M Varjosalo, C Qu, J Häyrinen, MJ Lammi - Proteomics, 2015 - Wiley Online Library
The idea of direct differentiation of somatic cells into other differentiated cell types has
attracted a great interest recently. Rho‐kinase inhibitor Y‐27632 (ROCKi) is a potential drug …
attracted a great interest recently. Rho‐kinase inhibitor Y‐27632 (ROCKi) is a potential drug …