ADP-ribosylation is an intricate and versatile posttranslational modification involved in the
regulation of a vast variety of cellular processes in all kingdoms of life. Its complexity derives …

Skeletal muscle plays a pivotal role in the maintenance of physical and metabolic health
and, critically, mobility. Accordingly, strategies focused on increasing the quality and quantity …

Gene co-expression analysis has emerged as a powerful method to provide insights into
gene function and regulation. The rapid growth of publicly available RNA-sequencing (RNA …

Revealing the mechanisms underlying the reversible physiology of hibernation could have
applications to both human and animal health as hibernation is often associated with …

The hypoxic state of the tumor microenvironment leads to reprogramming lipid metabolism
in tumor cells. ATGL, as an essential lipid metabolism-regulating enzyme in cells, is …

Emerging evidence has linked Alzheimer's disease (AD) onset with musculoskeletal aging
via a muscle-brain crosstalk mediated by dysregulation of the mitochondrial …

Simple Summary The molecular mechanisms of Charcot–Marie–Tooth (CMT) disease,
involving impaired vitamin metabolism and/or actions, are considered in light of the potential …

Simple Summary Reproduction plays a pivotal role in dairy cow farming. Good reproductive
performance in cows can decrease the elimination rate of cows, increase the success rate of …

Abstract Background Trisomy 21 (T21) is a genetic alteration characterised by the presence
of an extra full or partial human chromosome 21 (Hsa21) leading to Down syndrome (DS) …

Background The mitochondrial gene MCCC2, a subunit of the heterodimer of 3-
methylcrotonyl-CoA carboxylase, plays a pivotal role in catabolism of leucine and isovaleric …