Histones are the main components of chromatin, functioning as an instructive scaffold to
maintain chromosome structure and regulate gene expression. The dysregulation of histone …

Because of the low mutational burden, children with acute myeloid leukemia (AML) are
thought to have a 'cold'tumor microenvironment and consequently, a low likelihood of …

Glioblastoma (GBM) is the most common primary malignant brain tumor, with a median
overall survival of less than 2 years and a nearly 100% mortality rate under standard therapy …

Therapeutically manipulating the stimulator of interferon genes (STING) pathway has
promising potential for enhancing antitumor immunity. Agonists of this pathway (STING …

Suppressor of cytokine signaling 1 (SOCS1) is a potent regulator immune cell responses
and a proven tumor suppressor. Inhibition of SOCS1 in T cells can boost antitumor immunity …

Abstract Purpose: Classic Hodgkin lymphoma (cHL) is a B-cell lymphoma that occurs
primarily in young adults and, less frequently, in elderly individuals. A hallmark of cHL is the …

The mononuclear phagocyte system includes monocytes, macrophages, some dendritic
cells, and multinuclear giant cells. These cell populations display marked heterogeneity …

Deciphering cellular components and the spatial interaction network of the tumor immune
microenvironment (TIME) of solid tumors is pivotal for understanding biologically relevant …

Tumor invasion into the lymphatic vasculature represents a critical step during malignant
progression of epithelial cancers. In this issue of Cancer Cell, Zheng et al. unravel how …

Abstract Programmed death 1 (PD‐1)/programmed death‐ligand 1 inhibitors are commonly
used to treat various cancers, including melanoma. However, their efficacy as monotherapy …