Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China
L Yang, Z Wang - European Journal of Medicinal Chemistry, 2023 - Elsevier
The ongoing COVID-19 pandemic has resulted in millions of deaths globally, highlighting
the need to develop potent prophylactic and therapeutic strategies against SARS-CoV-2 …
the need to develop potent prophylactic and therapeutic strategies against SARS-CoV-2 …
[HTML][HTML] Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages
Recently, a large number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) variants continuously emerged and posed a major threat to global public health. Among …
2) variants continuously emerged and posed a major threat to global public health. Among …
[PDF][PDF] Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants
The BQ and XBB subvariants of SARS-CoV-2 Omicron are now rapidly expanding, possibly
due to altered antibody evasion properties deriving from their additional spike mutations …
due to altered antibody evasion properties deriving from their additional spike mutations …
Antigenicity and receptor affinity of SARS-CoV-2 BA. 2.86 spike
A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant, BA.
2.86, has emerged and spread to numerous countries worldwide, raising alarm because its …
2.86, has emerged and spread to numerous countries worldwide, raising alarm because its …
Antigenicity and infectivity characterisation of SARS-CoV-2 BA. 2.86
S Yang, Y Yu, F Jian, W Song, A Yisimayi… - The Lancet Infectious …, 2023 - thelancet.com
The newly emerged SARS-CoV-2 saltation variant, BA. 2.86, has raised global concern
(appendix 1 p 7). By Sept 8, 2023, 95 sequences were detected, of which their early …
(appendix 1 p 7). By Sept 8, 2023, 95 sequences were detected, of which their early …
[HTML][HTML] Neutralization, effector function and immune imprinting of Omicron variants
Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots
in the receptor-binding domain (RBD) of the spike protein. The effects of these mutations on …
in the receptor-binding domain (RBD) of the spike protein. The effects of these mutations on …
The altered entry pathway and antigenic distance of the SARS-CoV-2 Omicron variant map to separate domains of spike protein
TP Peacock, JC Brown, J Zhou, N Thakur, K Sukhova… - biorxiv, 2022 - biorxiv.org
At the end of 2021 a new SARS-CoV-2 variant, Omicron, emerged and quickly spread
across the world. It has been demonstrated that Omicron's high number of Spike mutations …
across the world. It has been demonstrated that Omicron's high number of Spike mutations …
Deep-learning-enabled protein–protein interaction analysis for prediction of SARS-CoV-2 infectivity and variant evolution
G Wang, X Liu, K Wang, Y Gao, G Li… - Nature Medicine, 2023 - nature.com
Host–pathogen interactions and pathogen evolution are underpinned by protein–protein
interactions between viral and host proteins. An understanding of how viral variants affect …
interactions between viral and host proteins. An understanding of how viral variants affect …
[HTML][HTML] A tripartite rheostat controls self-regulated host plant resistance to insects
J Guo, H Wang, W Guan, Q Guo, J Wang, J Yang… - Nature, 2023 - nature.com
Plants deploy receptor-like kinases and nucleotide-binding leucine-rich repeat receptors to
confer host plant resistance (HPR) to herbivores. These gene-for-gene interactions between …
confer host plant resistance (HPR) to herbivores. These gene-for-gene interactions between …
[HTML][HTML] Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA. 2 variant compared to BA. 1 and their possible mouse …
The Omicron BA. 2 variant has become a dominant infective strain worldwide. Receptor
binding studies show that the Omicron BA. 2 spike trimer exhibits 11-fold and 2-fold higher …
binding studies show that the Omicron BA. 2 spike trimer exhibits 11-fold and 2-fold higher …