Focus on the contribution of oxidative stress in skin aging

F Papaccio, AD′ Arino, S Caputo, B Bellei - Antioxidants, 2022 - mdpi.com
Skin aging is one of the most evident signs of human aging. Modification of the skin during
the life span is characterized by fine lines and wrinkling, loss of elasticity and volume, laxity …

Skin aging, cellular senescence and natural polyphenols

E Csekes, L Račková - International journal of molecular sciences, 2021 - mdpi.com
The skin, being the barrier organ of the body, is constitutively exposed to various stimuli
impacting its morphology and function. Senescent cells have been found to accumulate with …

Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

[HTML][HTML] Connective tissue and fibroblast senescence in skin aging

M Wlaschek, P Maity, E Makrantonaki… - Journal of Investigative …, 2021 - Elsevier
There is increasing evidence that skin aging is significantly enforced by the accumulation of
senescent dermal fibroblasts. Various stressors damaging macromolecules inside and …

[HTML][HTML] Cellular senescence and the senescence-associated secretory phenotype as drivers of skin photoaging

E Fitsiou, T Pulido, J Campisi, F Alimirah… - Journal of Investigative …, 2021 - Elsevier
Chronic exposure to UVR is known to disrupt tissue homeostasis, accelerate the onset of
age-related phenotypes, and increase the risk for skin cancer—a phenomenon defined as …

Effects of air pollution on cellular senescence and skin aging

I Martic, P Jansen-Dürr, M Cavinato - Cells, 2022 - mdpi.com
The human skin is exposed daily to different environmental factors such as air pollutants and
ultraviolet (UV) light. Air pollution is considered a harmful environmental risk to human skin …

The biology of human hair greying

JDB O'Sullivan, C Nicu, M Picard, J Chéret… - Biological …, 2021 - Wiley Online Library
Hair greying (canities) is one of the earliest, most visible ageing‐associated phenomena,
whose modulation by genetic, psychoemotional, oxidative, senescence‐associated …

Cell aging and cellular senescence in skin aging—Recent advances in fibroblast and keratinocyte biology

F Gruber, C Kremslehner, L Eckhart… - Experimental gerontology, 2020 - Elsevier
The aging of the skin is the most visible and obvious manifestation of organismal aging and
may serve as a predictor of life expectancy and health. It is, however, also the human desire …

Dynamic Stimulations with Bioengineered Extracellular Matrix‐Mimicking Hydrogels for Mechano Cell Reprogramming and Therapy

Y Shou, XY Teo, KZ Wu, B Bai, ARK Kumar… - Advanced …, 2023 - Wiley Online Library
Cells interact with their surrounding environment through a combination of static and
dynamic mechanical signals that vary over stimulus types, intensity, space, and time …

Mesenchymal stem cell senescence and rejuvenation: current status and challenges

X Zhou, Y Hong, H Zhang, X Li - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Over the past decades, mesenchymal stem cell (MSC)-based therapy has been intensively
investigated and shown promising results in the treatment of various diseases due to their …