Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics,
one of the newer omics technologies, has emerged as a powerful tool for defining changes …

Ischaemic heart disease and the heart failure that often results, remain the leading causes of
death and disability in Europe and worldwide. As such, in order to prevent heart failure and …

Perturbations in cardiac energy metabolism are major contributors to a number of
cardiovascular pathologies. In addition, comorbidities associated with cardiovascular …

Chronic kidney disease (CKD) results in systemic inflammation and oxidative stress which
play a central role in CKD progression and its adverse consequences. Although many of the …

The study of biological systems in a holistic manner (systems biology) is increasingly being
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …

SIRT6 is a member of a highly conserved family of NAD+-dependent deacetylases with
various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop …

'Omic'technologies adopt a holistic view of the molecules that make up a cell, tissue or
organism. They are aimed primarily at the universal detection of genes (genomics), mRNA …

The premier single-volume reference in the field of anesthesia, Clinical Anesthesia is now in
its Sixth Edition, with thoroughly updated coverage, a new full-color design, and a revamped …

Calcific aortic valve disease sits at the confluence of multiple world-wide epidemics of aging,
obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over …

Exercise provides numerous salutary effects, but our understanding of how these occur is
limited. To gain a clearer picture of exercise-induced metabolic responses, we have …