Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

The pivotal role of calcitonin gene-related peptide (CGRP) in migraine pathophysiology was
identified over 30 years ago, but the successful clinical development of targeted therapies …

Although nutrient-starvation therapies can elicit strong anti-tumor effects in multiple
carcinomas, it has been convincingly demonstrated that cancer cells exploit the tumor …

Background The clinical efficacy of migraine therapeutic agents directed towards the
calcitonin-gene related peptide (CGRP) pathway has confirmed the key role of this axis in …

Background Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show
good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to …

ABSTRACT Introduction Calcitonin Gene-Related Peptide (CGRP) has gradually emerged
as a suitable therapeutic target to treat migraine. Considering the social and economic …

Small arteries, which play important roles in controlling blood flow, blood pressure, and
capillary pressure, are under nervous influence. Their innervation is predominantly …

Migraines constitute a common neurological and headache disorder affecting around 15%
of the world's population. In addition to other mechanisms, neurogenic neuroinflammation …

Background Vestibular symptoms are frequently reported in patients with chronic migraine
(CM). However, whether vestibular symptoms arise through overlapping neurobiology of …

Calcitonin gene-related peptide (CGRP) has 37 amino acids. Initially, CGRP had
vasodilatory and nociceptive effects. As research progressed, evidence revealed that the …