Ecology, evolution and spillover of coronaviruses from bats

M Ruiz-Aravena, C McKee, A Gamble, T Lunn… - Nature Reviews …, 2022 - nature.com
In the past two decades, three coronaviruses with ancestral origins in bats have emerged
and caused widespread outbreaks in humans, including severe acute respiratory syndrome …

The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China

Y Yang, F Peng, R Wang, K Guan, T Jiang, G Xu… - Journal of …, 2020 - Elsevier
The 2019-nCoV is officially called SARS-CoV-2 and the disease is named COVID-19. This
viral epidemic in China has led to the deaths of over 1800 people, mostly elderly or those …

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

S Khan, MS Shafiei, C Longoria, JW Schoggins… - Elife, 2021 - elifesciences.org
The pathogenesis of COVID-19 is associated with a hyperinflammatory response; however,
the precise mechanism of SARS-CoV-2-induced inflammation is poorly understood. Here …

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

X Ou, Y Liu, X Lei, P Li, D Mi, L Ren, L Guo… - Nature …, 2020 - nature.com
Abstract Since 2002, beta coronaviruses (CoV) have caused three zoonotic outbreaks,
SARS-CoV in 2002–2003, MERS-CoV in 2012, and the newly emerged SARS-CoV-2 in late …

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

M Letko, A Marzi, V Munster - Nature microbiology, 2020 - nature.com
Over the past 20 years, several coronaviruses have crossed the species barrier into
humans, causing outbreaks of severe, and often fatal, respiratory illness. Since SARS-CoV …

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

DH Brann, T Tsukahara, C Weinreb, M Lipovsek… - Science …, 2020 - science.org
Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A
key question is whether SARS-CoV-2 (CoV-2)–the causal agent in COVID-19–affects …

[HTML][HTML] COVID-19 infection: Emergence, transmission, and characteristics of human coronaviruses

MA Shereen, S Khan, A Kazmi, N Bashir… - Journal of advanced …, 2020 - Elsevier
Abstract The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic
viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

LA Bienvenu, J Noonan, X Wang… - Cardiovascular …, 2020 - academic.oup.com
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic …

Coronavirus membrane fusion mechanism offers a potential target for antiviral development

T Tang, M Bidon, JA Jaimes, GR Whittaker, S Daniel - Antiviral research, 2020 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the
need to develop effective therapies against the causative agent, SARS-CoV-2, and also …

Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and …

KPY Hui, MC Cheung, RAPM Perera, KC Ng… - The Lancet …, 2020 - thelancet.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in
December 2019, causing a respiratory disease (coronavirus disease 2019, COVID-19) of …