Lipopolysaccharide modification in Gram-negative bacteria during chronic infection

RF Maldonado, I Sá-Correia… - FEMS microbiology …, 2016 - academic.oup.com
The Gram-negative bacterial lipopolysaccharide (LPS) is a major component of the outer
membrane that plays a key role in host–pathogen interactions with the innate immune …

Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections

B Rada, TL Leto - Trends in microbiology, 2013 - cell.com
Pseudomonas aeruginosa (PA) uses several virulence factors to establish chronic
respiratory infections in bronchiectasis, chronic obstructive pulmonary disease, and cystic …

The role of multispecies social interactions in shaping Pseudomonas aeruginosa pathogenicity in the cystic fibrosis lung

S O'Brien, JL Fothergill - FEMS microbiology letters, 2017 - academic.oup.com
Pseudomonas aeruginosa is a major pathogen in the lungs of cystic fibrosis (CF) patients.
However, it is now recognised that a diverse microbial community exists in the airways …

Adaptation of Pseudomonas aeruginosa in Cystic Fibrosis Airways Influences Virulence of Staphylococcus aureus In Vitro and Murine Models of Co-Infection

R Baldan, C Cigana, F Testa, I Bianconi, M De Simone… - PloS one, 2014 - journals.plos.org
Cystic fibrosis (CF) airways disease represents an example of polymicrobial infection
whereby different bacterial species can interact and influence each other. In CF patients …

Cystic fibrosis–adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses

SL LaFayette, D Houle, T Beaudoin, G Wojewodka… - Science …, 2015 - science.org
Cystic fibrosis lung disease is characterized by chronic airway infections with the
opportunistic pathogen Pseudomonas aeruginosa and severe neutrophilic pulmonary …

The changing landscape of the cystic fibrosis lung environment: from the perspective of Pseudomonas aeruginosa

MA Greenwald, MC Wolfgang - Current Opinion in Pharmacology, 2022 - Elsevier
This review guides the reader through the current understanding of the dynamic changes
that occur within the cystic fibrosis (CF) lung that allow Pseudomonas aeruginosa to become …

Reestablishment of recipient-associated microbiota in the lung allograft is linked to reduced risk of bronchiolitis obliterans syndrome

DL Willner, P Hugenholtz, ST Yerkovich… - American journal of …, 2013 - atsjournals.org
Rationale: Bronchiolitis obliterans syndrome (BOS) is the primary limiting factor for long-term
survival after lung transplantation, and has previously been associated with microbial …

The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research

E Jordana-Lluch, IM Barceló… - Frontiers in …, 2023 - frontiersin.org
The interplay between antibiotic resistance and bacterial fitness/virulence has attracted the
interest of researchers for decades because of its therapeutic implications, since it is …

Uncovering the novel Enterobacter cloacae complex species responsible for septic shock deaths in newborns: a cohort study

D Girlich, S Ouzani, C Emeraud, L Gauthier… - The Lancet …, 2021 - thelancet.com
Background Enterobacter cloacae complex contains nosocomial pathogens responsible for
infection outbreaks. Identification at the species level within the E cloacae complex remains …

Developing an international Pseudomonas aeruginosa reference panel

A De Soyza, AJ Hall, E Mahenthiralingam… - …, 2013 - Wiley Online Library
Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis (CF) patients
and causes a wide range of infections among other susceptible populations. Its inherent …