Folliculin (FLCN) is a tumor suppressor gene responsible for the inherited Birt-Hogg-Dubé
(BHD) syndrome, which affects kidneys, skin and lungs. FLCN is a highly conserved protein …

Asgard is a recently discovered superphylum of archaea that appears to include the closest
archaeal relatives of eukaryotes,,,–. Debate continues as to whether the archaeal ancestor …

Lysosomal storage diseases (LSDs) comprise a group of inherited monogenic disorders
characterized by lysosomal dysfunctions due to undegraded substrate accumulation. They …

Genetic variation at the leucine-rich repeat kinase 2 (LRRK2) locus contributes to an
enhanced risk of familial and sporadic Parkinson's disease. Previous data have …

Ion homeostasis, which is regulated by ion channels, is crucial for intracellular signaling.
These channels are involved in diverse signaling pathways, including cell proliferation …

Human papillomavirus (HPV) infects epithelial basal cells in the mucosa and either
proliferates with the differentiation of the basal cells or persists in them. Multiple host factors …

Renal cell cancer (RCC) involves three most recurrent sporadic types: clear-cell RCC (70–
75%, CCRCC), papillary RCCC (10–15%, PRCC), and chromophobe RCC (5%, CHRCC) …

The rare, fatal neurodegenerative disorder Niemann-Pick disease type C1 (NPC1) arises
from lysosomal accumulation of unesterified cholesterol and glycosphingolipids. These …

Abstract Folliculin interacting protein 1 (FNIP1), a novel folliculin interacting protein 1, is a
key regulatory factor for mitochondrial function. FNIP1 mainly responds to energy signal …

Summary Background Birt-Hogg-Dubé syndrome is a rare genetic tumor syndrome
characterized by renal cell cancer, lung bullae, pneumothorax, and fibrofolliculoma. Patients …