[HTML][HTML] Long non-coding RNA in the pathogenesis of cancers

Y Chi, D Wang, J Wang, W Yu, J Yang - Cells, 2019 - mdpi.com
The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

[HTML][HTML] Mechanisms of circRNA/lncRNA-miRNA interactions and applications in disease and drug research

B Ma, S Wang, W Wu, P Shan, Y Chen, J Meng… - Biomedicine & …, 2023 - Elsevier
In recent years, breakthroughs in bioinformatics have been made with the discovery of many
functionally significant non-coding RNAs (ncRNAs). The discovery of these ncRNAs has …

Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides

KA Lennox, MA Behlke - Nucleic acids research, 2016 - academic.oup.com
Thousands of long non-coding RNAs (lncRNAs) have been identified in mammalian cells.
Some have important functions and their dysregulation can contribute to a variety of disease …

[HTML][HTML] HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer

GSR Raju, E Pavitra, SS Bandaru, GL Varaprasad… - Molecular cancer, 2023 - Springer
HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose
expression is strongly correlated with the tumor grade and prognosis of a variety of …

LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer

A Bhan, SS Mandal - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2015 - Elsevier
Non-coding RNAs (ncRNAs) are emerging classes of regulatory RNA that play key roles in
various cellular and physiological processes such as in gene regulation, chromatin …

[HTML][HTML] Functions of lncRNA HOTAIR in lung cancer

G Loewen, J Jayawickramarajah, Y Zhuo… - Journal of hematology & …, 2014 - Springer
Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes.
lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through …

Long noncoding RNA and cancer: a new paradigm

A Bhan, M Soleimani, SS Mandal - Cancer research, 2017 - AACR
In addition to mutations or aberrant expression in the protein-coding genes, mutations and
misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to …

[HTML][HTML] HOTAIR: an oncogenic long non-coding RNA in different cancers

M Hajjari, A Salavaty - Cancer biology & medicine, 2015 - ncbi.nlm.nih.gov
Long non-coding RNAs (lncRNAs) refer to a group of RNAs that are usually more than 200
nucleotides and are not involved in protein generation. Instead, lncRNAs are involved in …

HOTAIR LncRNA: a novel oncogenic propellant in human cancer

T Rajagopal, S Talluri, RL Akshaya, NR Dunna - Clinica chimica acta, 2020 - Elsevier
Long non-coding RNAs (lncRNAs) are an important novel class of non-coding RNAs having
lengths of 200 nucleotides and low expression. The HOX Transcript Antisense Intergenic …

Long non-coding RNAs as emerging regulators of differentiation, development, and disease

BK Dey, AC Mueller, A Dutta - Transcription, 2014 - Taylor & Francis
A significant portion of the mammalian genome encodes numerous transcripts that are not
translated into proteins, termed long non-coding RNAs. Initial studies identifying long non …