Copper serves as a vital microelement which is widely present in the biosystem, functioning
as multi-enzyme active site, including oxidative stress, lipid oxidation and energy …

Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …

It has been reported that disordered Cu metabolism is associated with several
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …

Chrysin is a natural flavonoid compound that has antioxidant and neuroprotective effects.
Cerebral ischemia reperfusion (CIR) is closely connected with increased oxidative stress in …

The pollution of heavy metals (HMs) in the environment is a significant global environmental
issue, characterized by its extensive distribution, severe contamination, and profound …

Heavy metals, including lead (Pb), cadmium (Cd), arsenic (As), cobalt (Co), copper (Cu),
manganese (Mn), zinc (Zn), and others, have a significant impact on the development and …

Oxygen metabolism abnormality plays a crucial role in the pathogenesis of Alzheimer's
disease (AD) via several mechanisms, including hypoxia, oxidative stress, and …

Mitochondria serve as sites for energy production and are essential for regulating various
forms of cell death induced by metal metabolism, targeted anticancer drugs, radiotherapy …

Copper (Cu) is an essential trace element in the brain and serves as an important cofactor
for numerous enzymes involved in a wide range of biochemical processes including …

Excessive oxygen free radicals and toxic substances are generated in cerebral ischemia-
reperfusion (I/R) process. Dexmedetomidine (DEX), a common anesthetic and sedative …