Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …

Hypoxia, a common feature of the tumor microenvironment in various types of cancers,
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …

Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response
to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are …

Normal cells produce adenosine 5′-triphosphate (ATP) mainly through mitochondrial
oxidative phosphorylation (OXPHOS) when oxygen is available. Most cancer cells, on the …

Background Myocardial infarction (MI) is a severe disease that often associated with
dysfunction of angiogenesis. Cell-based therapies for MI using mesenchymal stem cell …

Hypoxia is an integral component of the tumor microenvironment. Either as chronic or
cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible …

While the distant organ environment is known to support metastasis of primary tumors, its
metabolic roles in this process remain underdetermined. Here, in breast cancer models, we …

The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pro-inflammatory
immune receptor potentiating acute lung injury (ALI). However, the mechanism of TREM-1 …

Sonodynamic therapy (SDT) is noninvasive and possesses high body‐penetration depth,
showing great potential for the treatment of deep‐seated solid tumors. The efficacy of SDT …

Deoxynivalenol (DON) is the most frequently present mycotoxin contaminant in food and
feed, causing a variety of toxic effects in humans and animals. Currently, a series of …