The glutathione S-transferases (GST) represent a major group of detoxification enzymes. All
eukaryotic species possess multiple cytosolic and membrane-bound GST isoenzymes, each …

Free radicals are found to be involved in both initiation and promotion of multistage
carcinogenesis. These highly reactive compounds can act as initiators and/or promoters …

The glutathione transferases (EC 2.5. 1.18) are known as enzymes that catalyze the
nucleophilic attack of the sulfur atom of glutathione on electrophilic groups in a second …

Studies were conducted on the carcinogenic activity of butylated hydroxyanisole (BHA) in
rats and hamsters. To obtain information concerning the mechanism of action of BHA on the …

Induction of drug-metabolizing enzymes through the antioxidant response element (ARE)-
dependent transcription was initially implicated in chemoprevention against cancer by …

This book provides a survey of biochemical, physiological and histological biomarkers of
environmental stress, along with evaluations of the strengths and weaknesses of various …

Glutathione (GSH) fulfills several essential functions: Detoxification of free radicals and toxic
oxygen radicals, thiol-disulfide exchange and storage and transfer of cysteine. GSH is …

This chapter focuses on a number of enzymes and other proteins that show responses to
pollutants. It provides background information on the nature, function, and biological …

Adriamycin-resistant (AdrR) human breast cancer cells have been selected which exhibit
cross-resistance to a wide range of anti-cancer drugs. This multidrug-resistant phenotype is …

Glutathione (GSH) alone detoxifies electrophiles with an effectiveness which depends on
the rate of the reaction and the concentration of GSH. If electrophiles are substrates for GSH …