The catalyst-directed divergent synthesis, commonly termed as “divergent catalysis”, has
emerged as a promising technique as it allows chartering of structurally distinct products …

Abstract (Hetero) arenes continue to prove their indispensability in pharmaceuticals,
materials science, and synthetic chemistry. As such, the controllable modification of …

Synthetic chemistry aims to build up molecular complexity from simple feedstocks. However,
the ability to exert precise changes that manipulate the connectivity of the molecular …

Direct molecular editing of heteroarene carbon–hydrogen (C–H) bonds through consecutive
selective C–H functionalization has the potential to grant rapid access into diverse chemical …

Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

Herein, we report a reaction that selectively generates 3-arylpyridine and quinoline motifs by
inserting aryl carbynyl cation equivalents into pyrrole and indole cores, respectively. By …

Natural products (NPs) are important sources of clinical drugs due to their structural diversity
and biological prevalidation. However, the structural complexity of NPs leads to synthetic …

The early years of alkyne metathesis were marked by a somewhat ironic state of affairs: the
proposed mechanism was swiftly validated and more than one effective catalyst became …

Accomplished herein is a rearrangement strategy for the highly efficient assembly of
synthetically cumbersome while medicinally significant 2-amino-3-formyl chromones via …

Excising the nitrogen in secondary amines, and coupling the two residual fragments is a
skeletal editing strategy that can be used to construct molecules with new skeletons, but …