Divergent gold catalysis: unlocking molecular diversity through catalyst control
The catalyst-directed divergent synthesis, commonly termed as “divergent catalysis”, has
emerged as a promising technique as it allows chartering of structurally distinct products …
emerged as a promising technique as it allows chartering of structurally distinct products …
Skeletal editing of (hetero) arenes using carbenes
Z Liu, P Sivaguru, Y Ning, Y Wu… - Chemistry–A European …, 2023 - Wiley Online Library
Abstract (Hetero) arenes continue to prove their indispensability in pharmaceuticals,
materials science, and synthetic chemistry. As such, the controllable modification of …
materials science, and synthetic chemistry. As such, the controllable modification of …
Skeletal editing through direct nitrogen deletion of secondary amines
SH Kennedy, BD Dherange, KJ Berger, MD Levin - Nature, 2021 - nature.com
Synthetic chemistry aims to build up molecular complexity from simple feedstocks. However,
the ability to exert precise changes that manipulate the connectivity of the molecular …
the ability to exert precise changes that manipulate the connectivity of the molecular …
Molecular editing of aza-arene C–H bonds by distance, geometry and chirality
Direct molecular editing of heteroarene carbon–hydrogen (C–H) bonds through consecutive
selective C–H functionalization has the potential to grant rapid access into diverse chemical …
selective C–H functionalization has the potential to grant rapid access into diverse chemical …
Modulators of protein–protein interactions
LG Milroy, TN Grossmann, S Hennig… - Chemical …, 2014 - ACS Publications
Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …
Carbon atom insertion into pyrroles and indoles promoted by chlorodiazirines
BD Dherange, PQ Kelly, JP Liles… - Journal of the …, 2021 - ACS Publications
Herein, we report a reaction that selectively generates 3-arylpyridine and quinoline motifs by
inserting aryl carbynyl cation equivalents into pyrrole and indole cores, respectively. By …
inserting aryl carbynyl cation equivalents into pyrrole and indole cores, respectively. By …
Structural simplification of natural products
S Wang, G Dong, C Sheng - Chemical Reviews, 2019 - ACS Publications
Natural products (NPs) are important sources of clinical drugs due to their structural diversity
and biological prevalidation. However, the structural complexity of NPs leads to synthetic …
and biological prevalidation. However, the structural complexity of NPs leads to synthetic …
Alkyne metathesis on the rise
A Fürstner - Angewandte Chemie International Edition, 2013 - Wiley Online Library
The early years of alkyne metathesis were marked by a somewhat ironic state of affairs: the
proposed mechanism was swiftly validated and more than one effective catalyst became …
proposed mechanism was swiftly validated and more than one effective catalyst became …
Toward the generation of 2-amino-3-formyl difunctionalized chromones via Pd-enabled rearrangement strategy
Q Tong, RF Xiu, JH Chen, Y Zhang, BD Cui… - ACS …, 2023 - ACS Publications
Accomplished herein is a rearrangement strategy for the highly efficient assembly of
synthetically cumbersome while medicinally significant 2-amino-3-formyl chromones via …
synthetically cumbersome while medicinally significant 2-amino-3-formyl chromones via …
Natom deletion in nitrogen heterocycles
H Qin, W Cai, S Wang, T Guo, G Li… - Angewandte Chemie, 2021 - Wiley Online Library
Excising the nitrogen in secondary amines, and coupling the two residual fragments is a
skeletal editing strategy that can be used to construct molecules with new skeletons, but …
skeletal editing strategy that can be used to construct molecules with new skeletons, but …