For patients who survive the initial bleeding event of a ruptured brain aneurysm, delayed
cerebral ischemia (DCI) is one of the most important causes of mortality and poor …

Aneurysmal subarachnoid haemorrhage is a neurological syndrome with complex systemic
complications. The rupture of an intracranial aneurysm leads to the acute extravasation of …

Background Acute treatment of cerebral edema and elevated intracranial pressure is a
common issue in patients with neurological injury. Practical recommendations regarding …

Objective To report the ESICM consensus and clinical practice recommendations on fluid
therapy in neurointensive care patients. Design A consensus committee comprising 22 …

Introduction Triple-H therapy and its separate components (hypervolemia, hemodilution, and
hypertension) aim to increase cerebral perfusion in subarachnoid haemorrhage (SAH) …

Object Currently, mannitol is the recommended first choice for a hyperosmolar agent for use
in patients with elevated intracranial pressure (ICP). Some authors have argued that …

The mortality after aneurysmal subarachnoid hemorrhage (SAH) is 50%, and most survivors
suffer severe functional and cognitive deficits. Half of SAH patients deteriorate 5 to 14 days …

Abstract AS OUTCOMES HAVE improved for patients with aneurysmal subarachnoid
hemorrhage, most mortality and morbidity that occur today are the result of severe diffuse …

Background: The impact of osmotic therapies on brain oxygen has not been extensively
studied in humans. We examined the effects on brain tissue oxygen tension (PbtO2) of …

Introduction This prospective randomized clinical study investigated the efficacy and safety
of 7.2% hypertonic saline hydroxyethyl starch 200/0.5 (7.2% NaCl/HES 200/0.5) in …