This study aimed to prove the prostate cancer chemopreventive activity of compounds
isolated from CA. We evaluated these compounds using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5 …

The roles and molecular interactions of polyamines (PAs) in the nucleus are not fully
understood. Here their effect on nucleosome stability, a key regulatory factor in eukaryotic …

Prostate cancer (PCa) is one of the most common tumors affecting men all over the world.
PCa has brought a huge health burden to men around the world, especially for elderly men …

Prostate cancer (PCa), a multifocal clinically heterogeneous disease, is the most commonly
diagnosed non-cutaneous neoplasm in men worldwide. The epigenome of PCa is a typical …

Abstract Background Prostate cancer (PCa) tumors harboring translocations of ETS family
genes with the androgen responsive TMPRSS2 gene (ETS+ tumors) provide a robust …

Background Exercise is increasingly recognized as an effective strategy to improve cancer
prevention and prognosis. Several biological mechanisms mediating these benefits have …

Epigenetics refers to mitotically/meiotically heritable mechanisms that regulate gene
transcription without a need for changes in the DNA code. Covalent modifications of DNA, in …

Background Prognostic biomarkers for localized prostate cancer (PCa) could improve
personalized medicine. Our group previously identified a panel of differentially methylated …

Studies have suggested that abrogated expression of detoxification enzymes, UGT2B15 and
UGT2B17, are associated with prostate tumour risk and progression. We investigated the …

The role of epigenetic alteration in prostate cancer pathogenesis was reported. We aimed to
analyze dysregulation of DNA methylase (DNA methyl transferase/DNMT) and demethylase …