Clinical utility of circulating non-coding RNAs—an update

S Anfossi, A Babayan, K Pantel, GA Calin - Nature reviews Clinical …, 2018 - nature.com
Over the past decade, the amount of research and the number of publications on
associations between circulating small and long non-coding RNAs (ncRNAs) and cancer …

Long non-coding RNAs and complex diseases: from experimental results to computational models

X Chen, CC Yan, X Zhang, ZH You - Briefings in bioinformatics, 2017 - academic.oup.com
LncRNAs have attracted lots of attentions from researchers worldwide in recent decades.
With the rapid advances in both experimental technology and computational prediction …

Long noncoding RNAs as biomarkers in cancer

L Bolha, M Ravnik-Glavač, D Glavač - Disease markers, 2017 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are a relatively well‐characterized class of noncoding
RNA (ncRNA) molecules, involved in the regulation of various cell processes, including …

MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches

N Amodio, L Raimondi, G Juli, MA Stamato… - Journal of hematology & …, 2018 - Springer
The deeper understanding of non-coding RNAs has recently changed the dogma of
molecular biology assuming protein-coding genes as unique functional biological effectors …

MicroRNAs and other non-coding RNAs as targets for anticancer drug development

H Ling, M Fabbri, GA Calin - Nature reviews Drug discovery, 2013 - nature.com
The first cancer-targeted microRNA (miRNA) drug—MRX34, a liposome-based miR-34
mimic—entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in …

Long non-coding RNAs: a new frontier in the study of human diseases

X Shi, M Sun, H Liu, Y Yao, Y Song - Cancer letters, 2013 - Elsevier
With the development of whole genome and transcriptome sequencing technologies, long
noncoding RNAs (lncRNAs) have received increased attention. Multiple studies indicate that …

Curcumin mediates anticancer effects by modulating multiple cell signaling pathways

AB Kunnumakkara, D Bordoloi, C Harsha… - Clinical …, 2017 - portlandpress.com
Curcumin, a component of a spice native to India, was first isolated in 1815 by Vogel and
Pelletier from the rhizomes of Curcuma longa (turmeric) and, subsequently, the chemical …

The hallmarks of cancer: a long non-coding RNA point of view

T Gutschner, S Diederichs - RNA biology, 2012 - Taylor & Francis
With the advent of next generation sequencing methods and progress in transcriptome
analysis, it became obvious that the human genome contains much more than just protein …

Immune checkpoints in the tumor microenvironment

SM Toor, VS Nair, J Decock, E Elkord - Seminars in cancer biology, 2020 - Elsevier
Interactions between immune checkpoints (ICs) and their ligands negatively regulate T cell
activation pathways involved in physiological immune responses against specific antigens …

MicroRNAome genome: a treasure for cancer diagnosis and therapy

I Berindan‐Neagoe, PC Monroig… - CA: a cancer journal …, 2014 - Wiley Online Library
The interplay between abnormalities in genes coding for proteins and noncoding
microRNAs (miRNAs) has been among the most exciting yet unexpected discoveries in …