[HTML][HTML] Mucosal transmissibility, disease induction and coreceptor switching of R5 SHIVSF162P3Nmolecular clones in rhesus macaques
W Ren, A Mumbauer, K Zhuang, C Harbison, H Knight… - Retrovirology, 2013 - Springer
Background Mucosally transmissible and pathogenic CCR5 (R5)-tropic simian-human
immunodeficiency virus (SHIV) molecular clones are useful reagents to identity …
immunodeficiency virus (SHIV) molecular clones are useful reagents to identity …
Advances in HIV-1 entry inhibitors: strategies to interfere with receptor and coreceptor engagement
I Markovic - Current pharmaceutical design, 2006 - ingentaconnect.com
The present armamentarium of 19 antiretroviral drugs licensed for treatment of HIV-1
infection in the US exemplifies preponderance of scientific evidence, which led to improved …
infection in the US exemplifies preponderance of scientific evidence, which led to improved …
Coreceptor switch in infection of nonhuman primates
C Cheng-Mayer, S Tasca, S Ho - Current HIV research, 2009 - ingentaconnect.com
The human immunodeficiency virus (HIV) enters target cells via interaction of the viral
glycoprotein with the cellular receptor CD4 and two principal coreceptors, CCR5 (R5 …
glycoprotein with the cellular receptor CD4 and two principal coreceptors, CCR5 (R5 …
[HTML][HTML] Identification of interdependent variables that influence coreceptor switch in R5 SHIVSF162P3N-infected macaques
K Zhuang, A Finzi, J Toma, A Frantzell, W Huang… - Retrovirology, 2012 - Springer
Background We previously reported that adoption of an “open” envelope glycoprotein (Env)
to expose the CD4 binding site for efficient receptor binding and infection of cell targets such …
to expose the CD4 binding site for efficient receptor binding and infection of cell targets such …
Fitness disadvantage of transitional intermediates contributes to dynamic change in the infecting-virus population during coreceptor switch in R5 simian/human …
M Shakirzyanova, W Ren, K Zhuang, S Tasca… - Journal of …, 2010 - Am Soc Microbiol
Fitness disadvantage of the transitional intermediates compared to the initial R5 viruses has
been suggested to constitute one of the blockades to coreceptor switching, explaining the …
been suggested to constitute one of the blockades to coreceptor switching, explaining the …
[HTML][HTML] Defining the fitness of HIV-1 isolates with dual/mixed co-receptor usage
IL Nankya, DM Tebit, A Abraha, F Kyeyune… - AIDS Research and …, 2015 - Springer
Abstract Background CCR5-using (r5) HIV-1 predominates during asymptomatic disease
followed by occasional emergence of CXCR4-using (x4) or dual tropic (r5x4) virus. We …
followed by occasional emergence of CXCR4-using (x4) or dual tropic (r5x4) virus. We …
Distinct molecular pathways to X4 tropism for a V3-truncated human immunodeficiency virus type 1 lead to differential coreceptor interactions and sensitivity to a …
GQ Del Prete, GJ Leslie, B Haggarty… - Journal of …, 2010 - Am Soc Microbiol
During the course of infection, transmitted HIV-1 isolates that initially use CCR5 can acquire
the ability to use CXCR4, which is associated with an accelerated progression to AIDS …
the ability to use CXCR4, which is associated with an accelerated progression to AIDS …
Adaptation of a diverse simian immunodeficiency virus population to a new host is revealed through a systematic approach to identify amino acid sites under selection
TH Vanderford, LJ Demma, MB Feinberg… - Molecular biology …, 2007 - academic.oup.com
Simian immunodeficiency viruses (SIV) have had considerable success at crossing species
barriers; both human immunodeficiency virus (HIV)-1 and HIV-2 have been transmitted on …
barriers; both human immunodeficiency virus (HIV)-1 and HIV-2 have been transmitted on …
[HTML][HTML] The co-receptor signaling model of HIV-1 pathogenesis in peripheral CD4 T cells
Y Wu - Retrovirology, 2009 - Springer
HIV-mediated CD4 depletion is the hallmark of AIDS and is the most reliable predictor of
disease progression. While HIV replication is associated with CD4 depletion in general …
disease progression. While HIV replication is associated with CD4 depletion in general …
The role of the APOBEC3 family of cytidine deaminases in innate immunity, G-to-A hypermutation, and evolution of retroviruses
ML Santiago, WC Greene - Origin and evolution of viruses, 2008 - Elsevier
The APOBEC3 family of cytidine deaminases comprises a novel group of innate immunity
factors that counteract both exogenous and endogenous retroviruses. Initially identified as …
factors that counteract both exogenous and endogenous retroviruses. Initially identified as …