Next-generation TB vaccines: progress, challenges, and prospects

L Zhuang, Z Ye, L Li, L Yang, W Gong - Vaccines, 2023 - mdpi.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a prevalent global
infectious disease and a leading cause of mortality worldwide. Currently, the only available …

Key advances in vaccine development for tuberculosis—Success and challenges

R Lai, AF Ogunsola, T Rakib, SM Behar - NPJ vaccines, 2023 - nature.com
Breakthrough findings in the clinical and preclinical development of tuberculosis (TB)
vaccines have galvanized the field and suggest, for the first time since the development of …

The promising potential of reverse vaccinology-based next-generation vaccine development over conventional vaccines against antibiotic-resistant bacteria

K Khalid, CL Poh - Vaccines, 2023 - mdpi.com
The clinical use of antibiotics has led to the emergence of multidrug-resistant (MDR)
bacteria, leading to the current antibiotic resistance crisis. To address this issue, next …

VPM1002 as prophylaxis against severe respiratory tract infections including coronavirus disease 2019 in the elderly: a phase 3 randomized, double-blind, placebo …

AM Blossey, S Brückner, M May… - Clinical Infectious …, 2023 - academic.oup.com
Abstract Background Bacille Calmette-Guérin (BCG) vaccination can potentially reduce the
rate of respiratory infections in vulnerable populations. This study evaluates the safety and …

[HTML][HTML] The cost and cost-effectiveness of novel tuberculosis vaccines in low-and middle-income countries: A modeling study

A Portnoy, RA Clark, M Quaife, CK Weerasuriya… - PLoS …, 2023 - journals.plos.org
Background Tuberculosis (TB) is preventable and curable but eliminating it has proven
challenging. Safe and effective TB vaccines that can rapidly reduce disease burden are …

The potential impact of novel tuberculosis vaccine introduction on economic growth in low-and middle-income countries: A modeling study

A Portnoy, JL Arcand, RA Clark, CK Weerasuriya… - PLoS …, 2023 - journals.plos.org
Background Most individuals developing tuberculosis (TB) are working age adults living in
low-and middle-income countries (LMICs). The resulting disability and death impact …

Recent advance in the development of tuberculosis vaccines in clinical trials and virus-like particle-based vaccine candidates

F Zhou, D Zhang - Frontiers in Immunology, 2023 - frontiersin.org
Tuberculosis (TB) remains a serious public health threat around the world. An effective
vaccine is urgently required for cost-effective, long-term control of TB. However, the only …

A Structural View at Vaccine Development against M. tuberculosis

M Romano, F Squeglia, E Kramarska, G Barra… - Cells, 2023 - mdpi.com
Tuberculosis (TB) is still the leading global cause of death from an infectious bacterial agent.
Limiting tuberculosis epidemic spread is therefore an urgent global public health priority. As …

Bridging the gaps to overcome major hurdles in the development of next-generation tuberculosis vaccines

H Kim, HG Choi, SJ Shin - Frontiers in Immunology, 2023 - frontiersin.org
Although tuberculosis (TB) remains one of the leading causes of death from an infectious
disease worldwide, the development of vaccines more effective than bacille Calmette …

Recent developments in mycobacteria-based live attenuated vaccine candidates for tuberculosis

MA Flores-Valdez, A Kupz, S Subbian - Biomedicines, 2022 - mdpi.com
Vaccination is an excellent approach to stimulating the host immune response and reducing
human morbidity and mortality against microbial infections, such as tuberculosis (TB) …