The study of chronic pain continues to generate ever-increasing numbers of publications,
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …

The extracellular matrix (ECM) surrounds cells in the brain, providing structural and
functional support. Emerging studies demonstrate that the ECM plays important roles during …

Although largely confined to the airways, SARS-CoV-2 infection has been associated with
sensory abnormalities that manifest in both acute and chronic phenotypes. To gain insight …

Neuropathic pain (NeuP) arises due to injury of the somatosensory nervous system and is
both common and disabling, rendering an urgent need for non-addictive, effective new …

The Ehlers‒Danlos syndromes (EDS) constitute a heterogenous group of connective tissue
disorders characterized by joint hypermobility, skin abnormalities, and vascular fragility. The …

Chronic pain is one of the most common, yet poorly studied, complaints in people suffering
from Ehlers–Danlos syndromes (EDS). This heterogeneous group of heritable connective …

This study aimed to disclose differentially expressed genes (DEGs) in dorsal root ganglia
(DRGs) of neuropathic pain (NP) from spared nerve injury (SNI) model, thereby identifying …

Background Chronic primary pain (CPP) is an intractable pain of unknown cause with
significant emotional distress and/or dysfunction that is a leading factor of disability globally …

Objective: Determine if chronic low back pain (LBP) is associated with DNA methylation
signatures in human T cells that will reveal novel mechanisms and potential therapeutic …

The extracellular matrix (ECM) is a dynamic structure of molecules that can be divided into
six different categories and are collectively called the matrisome. The ECM plays pivotal …