Functional gastrointestinal disorders (FGIDs) are characterized by chronic complaints
arising from disorganized brain-gut interactions leading to dysmotility and hypersensitivity …

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose aetiology is
still unknown. Most hypotheses point out the gut-brain axis as a key factor for IBS. The axis is …

Objective To gain mechanistic insights, we compared effects of low fermentable
oligosaccharides, disaccharides and monosaccharides and polyols (FODMAP) and high …

Objective To determine the role of colonic barrier defects and low-grade inflammation in
irritable bowel syndrome (IBS)-like symptoms in quiescent inflammatory bowel disease …

Abstract Background & Aims Increases in mucosal immune cells have frequently been
observed in irritable bowel syndrome (IBS) patients. However, this finding is not completely …

The aetiology and pathology of IBS, a functional bowel disorder thought to lack an organic
cause, is largely unknown. However, studies suggest that various features, such as altered …

Irritable bowel syndrome (IBS) is traditionally defined as a functional disorder since it lacks
demonstrable pathological abnormalities. However, in recent years, low grade inflammatory …

OBJECTIVES: An intact and well-functioning enteric nervous system is necessary to
efficiently organize gut function. Functional gastrointestinal disorders are pathological …

Mast cells are key actors in inflammatory reactions. Upon activation, they release histamine,
heparin and nerve growth factor, among many other mediators that modulate immune …

Objective Low-grade intestinal inflammation plays a role in the pathophysiology of IBS. In
this trial, we aimed at evaluating the efficacy and safety of mesalazine in patients with IBS …