[HTML][HTML] Cannabinoid receptors and the endocannabinoid system: signaling and function in the central nervous system
S Zou, U Kumar - International journal of molecular sciences, 2018 - mdpi.com
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled …
Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled …
[HTML][HTML] Molecular targets of cannabidiol in neurological disorders
Cannabis has a long history of anecdotal medicinal use and limited licensed medicinal use.
Until recently, alleged clinical effects from anecdotal reports and the use of licensed …
Until recently, alleged clinical effects from anecdotal reports and the use of licensed …
Cannabinoid CB1 and CB2 Receptor Signaling and Bias
An agonist that acts through a single receptor can activate numerous signaling pathways.
Recent studies have suggested that different ligands can differentially activate these …
Recent studies have suggested that different ligands can differentially activate these …
CB1 cannabinoid receptor signaling and biased signaling
LM Leo, ME Abood - Molecules, 2021 - mdpi.com
The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout
the central nervous system that is a promising target for the treatment of various disorders …
the central nervous system that is a promising target for the treatment of various disorders …
GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
JE Lauckner, JB Jensen, HY Chen… - Proceedings of the …, 2008 - National Acad Sciences
The CB1 cannabinoid receptor mediates many of the psychoactive effects of Δ9THC, the
principal active component of cannabis. However, ample evidence suggests that additional …
principal active component of cannabis. However, ample evidence suggests that additional …
N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
Background Microglia provide continuous immune surveillance of the CNS and upon
activation rapidly change phenotype to express receptors that respond to chemoattractants …
activation rapidly change phenotype to express receptors that respond to chemoattractants …
CB1 cannabinoid receptors and their associated proteins
AC Howlett, LC Blume… - Current medicinal …, 2010 - ingentaconnect.com
CB1 receptors are G-protein coupled receptors (GPCRs) abundant in neurons, in which they
modulate neurotransmission. The CB1 receptor influence on memory and learning is well …
modulate neurotransmission. The CB1 receptor influence on memory and learning is well …
JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB1 receptor agonist
Background and purpose:'Spice'is an herbal blend primarily marketed in Europe as a mild
hallucinogen with prominent cannabis‐like effects and as a legal alternative to cannabis …
hallucinogen with prominent cannabis‐like effects and as a legal alternative to cannabis …
Molecular mechanism and cannabinoid pharmacology
LD Schurman, D Lu, DA Kendall, AC Howlett… - … Use Disorders: From …, 2020 - Springer
Since antiquity, Cannabis has provoked enormous intrigue for its potential medicinal
properties as well as for its unique pharmacological effects. The elucidation of its major …
properties as well as for its unique pharmacological effects. The elucidation of its major …
Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons
Modulation of type 1 cannabinoid receptor (CB 1) activity has been touted as a potential
means of treating addiction, anxiety, depression, and neurodegeneration. Different agonists …
means of treating addiction, anxiety, depression, and neurodegeneration. Different agonists …