Optogenetics has provided a revolutionary approach to dissecting biological phenomena.
However, the generation and use of optically active GPCRs in these contexts is limited and it …

Activation of G protein-coupled receptors results in multiple waves of signaling that are
mediated by heterotrimeric G proteins and the scaffolding proteins β-arrestin 1/2. Ligands …

Background & Objective: Cannabis is one of the earliest cultivated plants. Cannabis of
industrial utility and culinary value is generally termed as hemp. Conversely, cannabis that is …

Cannabinoids are a group of bioactive compounds abundantly present in Cannabis sativa
plant. The active components of cannabis with therapeutic potential are known as …

We have previously identified allosteric modulators of the cannabinoid CB1 receptor (Org
27569, PSNCBAM-1) that display a contradictory pharmacological profile: increasing the …

Background and Purpose The cannabinoid receptor type 1 (CB 1) has an allosteric binding
site. The drugs ORG 27569 {5‐chloro‐3‐ethyl‐N‐[2‐[4‐(1‐piperidinyl) phenyl] ethyl]‐1H …

'Spice'is an herbal blend that has been reported to produce cannabis-like effects when
smoked and is marketed as an alternative to marijuana. Synthetic additives have been …

G protein-coupled receptors (GPCRs) are the major transducers of external stimuli and key
therapeutic targets in many pathological conditions. When activated by different ligands, one …

The type-1 cannabinoid receptor (CB 1) is a promising drug target for a wide range of
diseases. However, many existing and novel candidate ligands for CB 1 have shown only …

Recreational consumption of synthetic cannabinoid receptor agonists (SCRAs) is a growing
crisis in public health in many parts of the world. AMB-FUBINACA is a member of this class …