In rodents, many exogenous and endogenous cannabinoids, such as anandamide (AEA)
and 2‐arachidonyl glycerol (2‐AG), have been shown to play an important role in certain …

Agonists stimulate cannabinoid 1 receptor (CB1R) internalization. Previous work suggests
that the extreme carboxy‐terminus of the receptor regulates this internalization–likely …

Chronic inflammation in rheumatoid arthritis (RA) is accompanied by activation of the
sympathetic nervous system, which can support the immune system to perpetuate …

Highlights•Cannabinoid receptors are pleiotropically-coupled GPCRs.•Few studies quantify
cannabinoid bias using Black and Leff's operational model.•Correlations between …

Endocannabinoids (eCB) are key regulators of excitatory/inhibitory neurotransmission at
cannabinoid‐1‐receptor (CB 1R)‐expressing axon terminals. The most abundant eCB in the …

Pain is a complex disorder with neurochemical and psychological components contributing
to the severity, the persistence, and the difficulty in adequately treating the condition. Opioid …

Background and purpose Arrestin or G protein bias may be desirable for novel cannabinoid
therapeutics. Arrestin‐2 and arrestin‐3 translocation to CB1 receptor have been suggested …

The aim of this study was to characterize inhibitory mechanisms on T cell receptor signaling
mediated by the cannabinoid receptors CB1 and CB2. Both receptors are coupled to G i/o …

The most frequently reported use of medical marijuana is for pain relief. However, its
psychoactive component Δ9-tetrahydrocannabinol (THC) causes significant side effects …

The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress
synaptic transmission and plays a major role in a diverse range of brain functions including …